24386-17-2Relevant academic research and scientific papers
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor
Coumar, Mohane Selvaraj,Tsai, Ming-Tsung,Chu, Chang-Ying,Uang, Biing-Jiun,Lin, Wen-Hsing,Chang, Chun-Yu,Chang, Teng-Yuan,Leou, Jiun-Shyang,Teng, Chi-Huang,Wu, Jian-Sung,Fang, Ming-Yu,Chen, Chun-Hwa,Hsu, John T.-A.,Wu, Su-Ying,Chao, Yu-Sheng,Hsieh, Hsing-Pang
experimental part, p. 255 - 267 (2010/12/18)
Herein we reveal a simple method for the identification of novel Aurora kinase A inhibitors through substructure searching of an in-house compound library to select compounds for testing. A hydrazone fragment conferring Aurora kinase activity and heterocy
REACTIONS AND SPECTRAL PROPERTIES OF 2-AMINO-3-CYANO-4,5-DISUBSTITUTED FURANE DERIVATIVES
Prousek, Josef,Jurasek, Adolf,Kovac, Jaroslav
, p. 1581 - 1588 (2007/10/02)
Propanedinitrile reacts with acyloins I-III to give 2-amino-3-cyano-4,5-disubstituted furanes IV-VI; the latter react with formamide to give 4-amino-5,6-disubstituted furopyrimidines VII-IX.The derivative IV reacts with acetanhydride to 2-acetylami
