24390-14-5 Usage
Uses
Used in Pharmaceutical Industry:
Doxycycline hyclate is used as an antibiotic for the treatment of various infections, including chlamydia, rickettsia, mycoplasma, and some spirochete infections. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.
Used in Dental Applications:
Doxycycline hyclate is used to inhibit matrix metalloproteinases at subantimicrobial doses, which can be beneficial in the treatment of adult periodontitis and other dental conditions.
Used in Research and Development:
Doxycycline hyclate has been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T). It is also used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. Additionally, it serves as a broad-spectrum inhibitor to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase, in studies on wound healing and tissue remodeling.
Used in Gene Expression Regulation:
Doxycycline hyclate can be used as a regulator for inducible gene expression systems, where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline, making it a valuable tool in research and development.
Brand Names:
Atridox (QLT); Doryx (Faulding); Doryx (Warner Chilcott); Doxy (Abraxis); Doxychel Hyclate (Rachelle); Periostat (CollaGenex); Vibramycin (Pfizer); Abadox; Bassado; Bio-tab; Clisemina; Cloran; Cyclidox; Diocimex; Docostyl; Dosil; Dotura; Doxatet; Doxi sergo; Doxicento; Doxifin; Doxilen; Doximycin; Doxiten bio; Doxivis; Doxy-100; Doxy-basan; Doxybiocin; Doxycyl; Doxy-diolan; Doxydyn; Doxyfim; Doxygram; Doxylag; Doxylan; Doxylar; Doxylets; Doxymycin; Doxy-p; Doxytem; Doxy-wolff; Dumoxin; Duradoxal; Esadoxi; Farmodoxi; Ghimadox; Gram-val; Granudoxy; Helvedoclyn; Icladox; Miraclin; Monocline; Monodoxin; Novelciclina; Philcociclina; Roxyne; Semelciclina; Sigadoxin; Solupen; Stamicina; Supracyclin; Tetrasan; Unacil; Vibracina; Vibramicina; Vibramycin hyclate; Vibraveineuse; Vibravenosa; Ximicina; Zadorin.
World Health Organization (WHO)
Doxycycline, a semi-synthetic tetracycline derivative, was first
introduced into medicine in 1960 for the treatment of bacterial, rickettsial and
amoebic infections. Although allergic manifestations are uncommon, injectable
preparations have occasionally resulted in severe anaphylactoid reactions. Clinical
features and the fact that asthmatic patients seemed to be particularly at risk lead
to suspect a sulfite preservative in the formulation more than doxycycline itself.
Rapid administration may also be a factor. Injectable preparations of doxycycline
hyclate are included in the WHO Model List of Essential Drugs.
Biochem/physiol Actions
Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Mode of action
Tetracycline antimicrobials bind to the bacterial 30S ribosomal subunit interfering with tRNA/mRNA interaction, ultimately inhibiting protein synthesis. Tetracyclines can inhibit the MMP enzyme family and inhibit mitochondrial biogenesis.
Check Digit Verification of cas no
The CAS Registry Mumber 24390-14-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,3,9 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 24390-14:
(7*2)+(6*4)+(5*3)+(4*9)+(3*0)+(2*1)+(1*4)=95
95 % 10 = 5
So 24390-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H/t7-,10+,14+,15-,17-,22-;/m0./s1
