24393-44-0

Usage

Uses

Used in Organic Synthesis:
(E)-2-cyano-3-(3-methoxyphenyl)-2-propenoic acid ethyl ester is utilized as a starting material for the synthesis of pharmaceutical drugs. Its unique structure and functional groups allow for further chemical reactions and modifications, contributing to the development of new and improved drugs.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (E)-2-cyano-3-(3-methoxyphenyl)-2-propenoic acid ethyl ester serves as an intermediate in the production of other chemical compounds. Its role in the synthesis process is crucial, as it can be transformed into various active pharmaceutical ingredients through a series of chemical reactions.
Used in Chemical Compound Production:
(E)-2-cyano-3-(3-methoxyphenyl)-2-propenoic acid ethyl ester is also employed in the production of other chemical compounds, showcasing its versatility and utility in the field of chemistry. Its properties and reactivity make it a sought-after compound for researchers and chemists working on the development of new materials and substances.

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 591-31-1 3-methoxy-benzaldehyde 
• 64-17-5 ethanol 
• 107-91-5 cyanoacetic acid amide 
• 59276-28-7 m-anisaldehyde dimethyl acetal 

Downstream Products

• 120238-17-7 3-cyano-3-(3-methoxyphenyl)propanenitrile 
• 321525-40-0 2-cyano-3-(3,4-dichlorophenyl)-3-(3-methoxyphenyl)propionic acid ethyl ester 
• 38913-02-9 3-(3-methoxyphenyl)-1-(methyl)pyrrolidine-2,5-dione 
• 120238-18-8 3-(3-methoxyphenyl)pyrrolidine-2,5-dione 
• 120238-27-9 1,4-dimethyl-3-(3-methoxyphenyl)-3-pyrroline-2,5-dione 
• 120238-22-4 4-ethoxalyl-3-(3-methoxyphenyl)-1-(methyl)pyrrolidine-2,5-dione 
• 475629-78-8 3-Cyano-4-(3-methoxy-phenyl)-7-methoxy-2-oxo-2H-chromene 
• 1313429-14-9 2-cyano-3-(3-methoxy-phenyl)-pentanoic acid ethyl ester 
• 515114-52-0 (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol 
• 175591-09-0 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol hydrochloride 
• 175591-09-0 tapentadol hydrochloride 
• 175591-23-8 tapentadol 
• 175591-22-7 (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine 
• 1313429-20-7 2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

Selenotungstates incorporating organophosphonate ligands and metal ions: synthesis, characterization, magnetism and catalytic efficiency in the Knoevenagel condensation reaction

Three sandwich-type TM-containing (TM = transition metal) organophosphonate-based polyoxotungstate clusters, [TM(H2O)4(SeW6O21)2{Co(OOCCH2NCH2PO3)2}3]12?(TM = Co, Ni), have been successfully synthesized, which are the first reported TM-containing organophosphonate-based selenotungstates. They were structurally characterized by PXRD analyses, IR spectroscopy, TGA analyses,etc. Magnetic measurements show that all three compounds exhibit antiferromagnetic interactions. Besides,Co1can be used as an efficient heterogeneous catalyst in the Knoevenagel condensation of benzaldehyde and ethyl cyanoacetate under mild conditions (60 °C), and exhibits satisfactory conversion (93%) and high selectivity (99%).

Synthesis of multifunctional polymer containing Ni-Pd NPs via thiol-ene reaction for one-pot cascade reactions

Recently, acid–base bifunctional catalysts have been considered due to their abilities, such as the simultaneous activation of electrophilic and nucleophilic species and their high importance in organic syntheses. However, the synthesis of acid–base catalysts is problematic due to the neutralization of acidic and basic groups. This work reports a facial approach to solve this problem via the synthesis of a novel bifunctional polymer using inexpensive materials and easy methods. In this way, at the first step, heterogeneous poly (styrene sulfonic acid-n-vinylimidazole) containing pentaerythritol tetra-(3-mercaptopropionate) (PETMP) and trimethylolpropane trimethacrylate (TMPTMA) cross-linkers were synthesized in the pores of a mesoporous silica structure using click reaction as a novel bifunctional acid–base catalyst. After that, Ni-Pd nanoparticles supported on poly (styrenesulfonic acid-n-vinylimidazole)/KIT-6 as a novel trifunctional heterogeneous acid–base-metal catalyst was prepared. The prepared catalysts were characterized by various techniques like FT-IR, TGA, ICP-AES, DRS-UV, TEM, FE-SEM, EDS-Mapping, and XRD. The synthesized catalysts were efficiently used as bifunctional/trifunctional catalysts for one-pot, deacetalization-Knoevenagel condensation and one-pot, three-step and a sequential reaction containing deacetalization-Knoevenagel condensation-reduction reaction. It is important to note that the synthesized catalyst showing high chemo-selectivity for the reduction of nitro group, alkenyl double bond and ester group in the presence of nitrile. Moreover, it was found that the different nanoparticles including Ni, Pd, and alloyed Ni-Pd showing different chemo-selectivity and catalytic activity in the reaction.

Layered double hydroxide anchored ionic liquids as amphiphilic heterogeneous catalysts for the Knoevenagel condensation reaction

In recent years, great attention has been dedicated to the development of heterogeneous base catalysts providing a green and sustainable process in benign aqueous media. Herein, the ionic liquid modified layered double hydroxide (LDH) based catalysts of L

l-Lysine Functionalized Polyacrylonitrile Fiber: A Green and Efficient Catalyst for Knoevenagel Condensation in Water

Abstract: The l-lysine functionalized polyacrylonitrile fiber (PANLF) was prepared by grafting the l-lysine into a commercially available polyacrylonitrile fiber and showed highly catalytic activity for Knoevenagel condensation reaction. With low temperature (45?°C) and short reaction time (1?h), the fiber catalyst was well applicable to Knoevenagel condensation of a wide range of aldehydes and the yields could reach up to 99%. Interestingly, only in water could the reaction take place smoothly (with a yield of 88%) and a polar micro-environment promoted reaction process had been proposed to explain this phenomenon. Besides, the fiber catalyst has advantages of easy preparation, high functional degree, strong mechanical strength and thermal stability, etc. And it can be reused at least 5 times without further treatment and performed well in scaled-up experiment (amplified 50 times) and flow chemistry experiment (no loss of catalytic activity after 48?h), which indicates its potential application in industry application. Graphical Abstract: [Figure not available: see fulltext.].

Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange

Metal-organic frameworks (MOFs) are gaining considerable attention not only because of their diverse structures but also due to their interesting properties and potential applications. However, fabrication of MOFs with desired structures and properties re

A carboxylate-rich metalloligand and its heterometallic coordination polymers: Syntheses, structures, topologies, and heterogeneous catalysis

This work reports three heterometallic coordination polymers (HCPs), namely, [{(1′)2Zn8Na2(H2O)21}·20H2O]n (2), [{(1′)(1')Cd8(H2O)21}·32H2/

A simple, efficient and green procedure for knoevenagel condensation in hydroxy-functionalized ionic liquids

An efficient and simple Knoevenagel condensation catalyzed by hydroxy-functionalized ionic liquids proceeded smoothly in high yields under ambient and solvent-free conditions. The condensation procedures of aryl aldehydes and 2,4-thiazolidinedione was involved in hydrogen bonding interactions between the hydroxy groups of the ILs and the carbonyl group of the aldehyde. The ionic liquids can be reused for five times without significant loss in activity.

Knoevenagel condensation reaction using ionic liquid [ADPQ][CF3SO3] as green and reusable catalyst

Knoevenagel condensation reaction of aromatic aldehydes with some active methylene compounds proceeded efficiently without solvent using ionic liquids as catalyst. The experimental results show that these ionic liquids have good catalytic activities to th

Classical Keggin Intercalated into Layered Double Hydroxides: Facile Preparation and Catalytic Efficiency in Knoevenagel Condensation Reactions

The family of polyoxometalate (POM) intercalated layered double hydroxide (LDH) composite materials has shown great promise for the design of functional materials with numerous applications. It is known that intercalation of the classical Keggin polyoxome

Facile One-Pot Synthesis of Amine-Functionalized Mesoporous Silica Nanospheres for Water-Medium Knoevenagel Reaction Under Microwave Irradiation

Amine-functionalized mesoporous silica nanospheres (～80 nm) (NH2-MSNS) were prepared by a co-condensation method using tetraethyl orthosilicate and aminopropyltrimethoxysilane. The catalytic activities of the NH2-MSNS catalysts were