243965-29-9

Upstream product

• 31643-49-9 4-Nitrophthalonitrile 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 23340-69-4 dimethyl 5-cyanoisophthalate 

Downstream Products

• 499793-30-5 N-(4-aminophenyl)-4-(3,5-dicarbonylphenoxy)phthalimide 
• 499793-31-6 5-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-isoindol-5-yloxy)-isophthalic acid 
• 499793-29-2 4-(3,5-dicarbonylphenoxy)phthalic anhydride 
• 499793-28-1 5-(3′,4′-dicarboxylphenoxy)-isophthalic acid 

Relevant academic research and scientific papers

A smart copper-phthalocyanine framework nanoparticle for enhancing photodynamic therapy in hypoxic conditions by weakening cells through ATP depletion

Hypoxia in solid tumors hinders the efficacy of photodynamic therapy (PDT). The route of generation of adenosine triphosphate (ATP) in hypoxic tumor cells comprises ineffective glycolysis processes, but ATP is crucial for rapid and uncontrolled growth and division. ATP depletion would inhibit DNA replication and glutathione (GSH) biosynthesis, which could inhibit the proliferation of cells and make them sensitive to PDT treatment. In this context, a nanoscale metal-organic framework nanoparticle consisting of Cu2+ and carboxyl-modified zinc phthalocyanine (ZnPc-(COOH)8) ({Cu8(ZnPc-(COOH)8)}n, ZPCN) was designed and prepared. In the dark cycle, ATP could remove Cu2+ from ZPCN and form a copper-ATP complex. ATP in the above complex could be destroyed by a copper-mediated Fenton reaction, which could finally induce ATP depletion to inhibit the proliferation of cells and make them sensitive to PDT treatment. In the light cycle, ZPCN could generate abundant cytotoxic reactive oxygen species to suppress tumor growth. These results demonstrated the potential applicability of the new strategy for achieving tumor treatment in hypoxic conditions by PDT.

Synthesis of some metallophthalocyanines with dimethyl 5-(phenoxy)- isophthalate substituents and evaluation of their antioxidant-antibacterial activities

The synthesis, characterization, spectral, antioxidant and antibacterial properties of dimethyl 5-(phenoxy)-isophthalate substituted Zinc, Cobalt, Copper, and Nickel phthalocyanines are reported. The novel compounds have been characterized by using electr

Monomer zinc phthalocyanine/upconversion nanoparticle coated with hyaluronic acid crosslinked gel as NIR light-activated drug for: In vitro photodynamic therapy

Carboxyl group modified zinc phthalocyanines (ZnPc) are classic and widely used photosensitizers (PSs) in upconversion nanoparticles (UCNPs) mediated photodynamic therapy (PDT) for tumor treatment. To improve the PDT activity of the complex system of ZnPc and UCNPs, many UCNPs with high red emission intensity were design and prepared. ZnPc-(COOH)4 tends to aggregate both in water and under physiological conditions, which can sharply decrease its PDT activity. Therefore, choosing monomeric COOH groups modified ZnPc as PSs is an alternative way to improve their activity. In this manuscript, three zinc(ii) phthalocyanines, substituted with 4 (ZnPc-(COOH)4), 8 (ZnPc-(COOH)8) and 16 (ZnPc-(COOH)16) COOH groups, were synthesized. A comparison of the results indicated that ZnPc-(COOH)16 existed in its monomeric form under physiological conditions because of its large substituents. Moreover, ZnPc-(COOH)16 showed superior singlet oxygen (1O2) generation ability when compared to ZnPc-(COOH)4 and ZnPc-(COOH)8. Therefore, we chose ZnPc-(COOH)16 as PSs for absorption on the surface of the UCNPs. Then, they were encapsulated by crosslinked methacrylated hyaluronic acid (m-HA), which provides active tumor accumulation ability by binding its overexpressed receptors on the surface of cancer cells. The resulting nanoparticles can be effectively taken up by cancer cells and shows strong near-infrared (NIR) light triggered PDT in vitro.

In situ phthalocyanine synthesis chemistry in flames towards molecular fireproof engineering

The boundaries between phthalocyanine synthesis and combustion chemistry were broken through to achieve molecular fireproofing via in situ phthalocyanine (Pcs) synthesis during combustion. Furthermore in situ Pcs chemistry achieves a flame-retarding organic thermoplastic polymer, showing state-of-the-art fire-safety performance and an ultra-low fire hazard. This journal is

Synthesis, electrochemistry and in situ spectroelectrochemistry of novel tetra dimethyl 5-oxyisophthalate substituted Co(II), Mn(III), and μ-oxo-dimer Fe(III) phthalocyanines

In this study, peripheral and non-peripheral tetra dimethyl 5-oxyisophthalate substituted cobalt(II), manganese(III) and μ-oxo-dimer Fe(III) phthalocyanines were synthesized by the reaction of dimethyl 5-hydroxyisophthalate with 1,2-dicyano-4-nitrobenzene/1,2-dicyano-3-nitrobenzen in dry N,N-dimethylformamide in the presence of anhydrous potassium carbonate. All purified phthalocyanine compounds were characterized by using FT-IR, UV-visible, MALDI-TOF mass spectrometry and elemental analyses results. Electron transfer properties of all novel cobalt(II), manganese(III) and μ-oxo-dimer Fe(III)phthalocyanine complexes were investigated by voltammetric and in situ spectroelectrochemical measurements in nonaqueous solution medium. Complexes were observed to display both metal-based and phthalocyanine ring-based reduction and oxidation electron transfer processes.

Synthesis of hyperbranched aromatic poly(amide-imide): Copolymerization of B′B2 monomer with A2 monomer

A hyperbranched aromatic poly(amide-imide) was prepared by the copolymerization of 4-(3,5-dicarboxyphenoxy)phthalic anhydride, a B′B2type monomer, and 1,4-phenylenediamine, an A2 type monomer. The rapid reaction between the anhydride and amino group led to the formation of the dominant imide intermediate which can be regarded as a new AB2 type of monomer. The intermediate, without isolation, was subjected to further polymerization in the presence of TPP/pyridine, as condensing agents, to give the hyperbranched poly(amide-imide), containing carboxylic acid chain ends. In comparison, the AB2 monomer was prepared separately, and the conventional self-polymerization of this monomer was also studied. The structures of the obtained polymers were characterized by FTIR and 1H NMR spectroscopy. The spectral data showed that these two polymers, prepared from two different synthetic approaches, have nearly identical structures. The degree of branching of the hyperbranched poly(amide - imide)s was estimated to be 60-61%. The terminal carboxylic acid groups were modified by reaction with a variety of aromatic amines to give the corresponding amide derivatives. The nature of the chain ends was shown to have a significant effect on the solubility and Tg of the hyperbranched poly(amide-imide)s.