243965-29-9Relevant articles and documents
A smart copper-phthalocyanine framework nanoparticle for enhancing photodynamic therapy in hypoxic conditions by weakening cells through ATP depletion
Gui, Li,Zhou, Jiahong,Zhou, Lin,Wei, Shaohua
, p. 2078 - 2088 (2018)
Hypoxia in solid tumors hinders the efficacy of photodynamic therapy (PDT). The route of generation of adenosine triphosphate (ATP) in hypoxic tumor cells comprises ineffective glycolysis processes, but ATP is crucial for rapid and uncontrolled growth and division. ATP depletion would inhibit DNA replication and glutathione (GSH) biosynthesis, which could inhibit the proliferation of cells and make them sensitive to PDT treatment. In this context, a nanoscale metal-organic framework nanoparticle consisting of Cu2+ and carboxyl-modified zinc phthalocyanine (ZnPc-(COOH)8) ({Cu8(ZnPc-(COOH)8)}n, ZPCN) was designed and prepared. In the dark cycle, ATP could remove Cu2+ from ZPCN and form a copper-ATP complex. ATP in the above complex could be destroyed by a copper-mediated Fenton reaction, which could finally induce ATP depletion to inhibit the proliferation of cells and make them sensitive to PDT treatment. In the light cycle, ZPCN could generate abundant cytotoxic reactive oxygen species to suppress tumor growth. These results demonstrated the potential applicability of the new strategy for achieving tumor treatment in hypoxic conditions by PDT.
Monomer zinc phthalocyanine/upconversion nanoparticle coated with hyaluronic acid crosslinked gel as NIR light-activated drug for: In vitro photodynamic therapy
Zhou, Lin,Chen, Enyi,Jin, Weiwei,Wang, Yue,Zhou, Jiahong,Wei, Shaohua
, p. 15170 - 15179 (2016)
Carboxyl group modified zinc phthalocyanines (ZnPc) are classic and widely used photosensitizers (PSs) in upconversion nanoparticles (UCNPs) mediated photodynamic therapy (PDT) for tumor treatment. To improve the PDT activity of the complex system of ZnPc and UCNPs, many UCNPs with high red emission intensity were design and prepared. ZnPc-(COOH)4 tends to aggregate both in water and under physiological conditions, which can sharply decrease its PDT activity. Therefore, choosing monomeric COOH groups modified ZnPc as PSs is an alternative way to improve their activity. In this manuscript, three zinc(ii) phthalocyanines, substituted with 4 (ZnPc-(COOH)4), 8 (ZnPc-(COOH)8) and 16 (ZnPc-(COOH)16) COOH groups, were synthesized. A comparison of the results indicated that ZnPc-(COOH)16 existed in its monomeric form under physiological conditions because of its large substituents. Moreover, ZnPc-(COOH)16 showed superior singlet oxygen (1O2) generation ability when compared to ZnPc-(COOH)4 and ZnPc-(COOH)8. Therefore, we chose ZnPc-(COOH)16 as PSs for absorption on the surface of the UCNPs. Then, they were encapsulated by crosslinked methacrylated hyaluronic acid (m-HA), which provides active tumor accumulation ability by binding its overexpressed receptors on the surface of cancer cells. The resulting nanoparticles can be effectively taken up by cancer cells and shows strong near-infrared (NIR) light triggered PDT in vitro.
Synthesis, electrochemistry and in situ spectroelectrochemistry of novel tetra dimethyl 5-oxyisophthalate substituted Co(II), Mn(III), and μ-oxo-dimer Fe(III) phthalocyanines
K?ksoy, Baybars,Soyer, Ok?an,Orman, Efe Baturhan,?zkaya, Ali Riza,Bulut, Mustafa
, p. 166 - 175 (2015/04/14)
In this study, peripheral and non-peripheral tetra dimethyl 5-oxyisophthalate substituted cobalt(II), manganese(III) and μ-oxo-dimer Fe(III) phthalocyanines were synthesized by the reaction of dimethyl 5-hydroxyisophthalate with 1,2-dicyano-4-nitrobenzene/1,2-dicyano-3-nitrobenzen in dry N,N-dimethylformamide in the presence of anhydrous potassium carbonate. All purified phthalocyanine compounds were characterized by using FT-IR, UV-visible, MALDI-TOF mass spectrometry and elemental analyses results. Electron transfer properties of all novel cobalt(II), manganese(III) and μ-oxo-dimer Fe(III)phthalocyanine complexes were investigated by voltammetric and in situ spectroelectrochemical measurements in nonaqueous solution medium. Complexes were observed to display both metal-based and phthalocyanine ring-based reduction and oxidation electron transfer processes.
