243967-42-2 Usage
Biological Activity
Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (K i values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μ M for PTP1B, CD45 D1D2, PTP β , PTP ε D1, SHP-1, PTP α D1 and LAR D1D2 respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 243967-42-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,3,9,6 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 243967-42:
(8*2)+(7*4)+(6*3)+(5*9)+(4*6)+(3*7)+(2*4)+(1*2)=162
162 % 10 = 2
So 243967-42-2 is a valid CAS Registry Number.
243967-42-2Relevant articles and documents
Synthesis of tetrasubstituted thiophenes on solid-support using the Gewald reaction
Castanedo, Georgette M.,Sutherlin, Daniel P.
, p. 7181 - 7184 (2001)
The Gewald reaction was performed on solid support. This reaction combines a ketone or aldehyde, an activated nitrile, and sulfur in the presence of a suitable amine base to make tri- and tetrasubstituted thiophenes. After optimizing conditions for maximum yield and purity, the scope of the reaction was investigated. Finally, this method is highlighted in the synthesis of two biologically relevant compounds.
