244024-09-7

Basic information

• Product Name: C₂₀H₃₈O₃Si
• Synonyms: C₂₀H₃₈O₃Si
• CAS NO: 244024-09-7
• Molecular Weight: 354.605
• Mol File: 244024-09-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₃₈O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₃₈O₃Si(244024-09-7)
• EPA Substance Registry System: C₂₀H₃₈O₃Si(244024-09-7)

Safety Data

• Hazardous Substances Data: 244024-09-7(Hazardous Substances Data)

Upstream product

• 194807-80-2 triisopropylsilyl 3-butynoate 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 244024-04-2 triisopropylsilyl 5-ccyclohexylpenta-2E,4E-dienoate 
• 175552-85-9 (2E,4E)-5-Cyclohexyl-penta-2,4-dienoyl chloride 

Relevant articles and documents

Total synthesis of (±)-nisamycin

We have developed a highly convergent synthesis of the manumycin-type m- C7N-antibiotic nisamycin that is applicable to other members of this family of antibiotics. The synthesis features a three-step sequence to the epoxyquinol core that serves as a scaffold for the attachment of the polyene side chains. The eastern polyene side chain was constructed via a novel organozirconocene-mediated synthesis. Zirconocene methodology was also applied to the synthesis of the polyene side chains of asukamycin. The southern side chain of nisamycin was introduced via a Stille reaction that employed a vinyl bromo ketone, derived from an acid-sensitive bromo ketal. Pd-mediated coupling of the vinyl bromide with a stannyl TIPS ester gave TIPS-protected nisamycin that was readily converted to the natural product.