244139-00-2

Basic information

• Product Name: 2-diethoxymethyl-6-phenyl-nicotinic acid methyl ester
• Synonyms: 2-diethoxymethyl-6-phenyl-nicotinic acid methyl ester
• CAS NO: 244139-00-2
• Molecular Weight: 315.369
• Mol File: 244139-00-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-diethoxymethyl-6-phenyl-nicotinic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-diethoxymethyl-6-phenyl-nicotinic acid methyl ester(244139-00-2)
• EPA Substance Registry System: 2-diethoxymethyl-6-phenyl-nicotinic acid methyl ester(244139-00-2)

Safety Data

• Hazardous Substances Data: 244139-00-2(Hazardous Substances Data)

Upstream product

• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 6065-82-3 Ethyl diethoxyacetate 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 

Relevant articles and documents

Synthesis of 6-Phenyl Substituted 2-Formylnicotinates

A verastile synthesis of 2-formylnicotinates 6 (R' = Me) and 7 (R' = Et) is described. 6-Phenyl substituted 2-diethoxymethylnicotinates 14/15 are prepared first starting by cyclocondensation of 3-amino-4,4-diethoxybut-2-enoates 12/13 with Mannich base hydrochlorides 1 or β-aminovinyl ketones 16. Subsequent hydrolysis of the acetal function in 14/15 gives rise to the title compounds.