244148-46-7Relevant academic research and scientific papers
Efficient synthesis of isogranulatimide C, an analogue of the marine G2 checkpoint inhibitor alkaloid isogranulatimide
Delfourne, Evelyne
, p. 6560 - 6561 (2011)
A three-step procedure to isogranulatimide C starting with the thermal condensation of 3-chloroindole with imidazole and proceeding in 41% yield is described.
Aryl[a]pyrrolo[3,4-c]carbazoles as selective Cyclin D1-CDK4 inhibitors
Sanchez-Martinez, Concha,Shih, Chuan,Faul, Margaret M.,Zhu, Guoxin,Paal, Michael,Somoza, Carmen,Li, Tiechao,Kumrich, Christine A.,Winneroski, Leonard L.,Xun, Zhou,Brooks, Harold B.,Patel, Bharvin K. R.,Schultz, Richard M.,DeHahn, Tammy B.,Spencer, Charles D.,Watkins, Scott A.,Considine, Eileen,Dempsey, Jack A.,Ogg, Catherine A.,Campbell, Robert M.,Anderson, Bryan A.,Wagner, Jill
, p. 3835 - 3839 (2007/10/03)
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D
Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Syntheses of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide, and Isogranulatimides A-C
Piers, Edward,Britton, Robert,Andersen, Raymond J.
, p. 530 - 535 (2007/10/03)
A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is described. Also reported are the syntheses of didemnimide C (18), isodidemnimide A (24), neodidemnimide A (36), 17-methylgranulatimide (9), and isogranulatimides A (10), B (11), and C (12). Compounds 9-12, congeners of isogranulatimide (6), are now available for biological evaluation.
