244218-51-7 Usage
Uses
JTC 801 is a novel opioid receptor-like1 (ORL1) receptor antagonist.
Biological Activity
High affinity, selective NOP receptor antagonist (K i = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ -, κ - and δ -opioid receptors respectively. In vivo shows anti-nociceptive effects in acute pain models. Orally active.
Check Digit Verification of cas no
The CAS Registry Mumber 244218-51-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,4,2,1 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 244218-51:
(8*2)+(7*4)+(6*4)+(5*2)+(4*1)+(3*8)+(2*5)+(1*1)=117
117 % 10 = 7
So 244218-51-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H25N3O2.ClH/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25;/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30);1H
244218-51-7Relevant articles and documents
FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT
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Page/Page column, (2015/06/16)
The present invention provides a highly effective substance having a filaggrin production-promoting action. The present invention also provides a therapeutic agent useful for treating a skin disease, in particular, atopic dermatitis associated with reduce
