244218-93-7

Basic information

• Product Name: JTC-801
• Synonyms: N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]Benzamide
• CAS NO: 244218-93-7
• Molecular Formula: C26H25N3O2
• Molecular Weight: 411.4956
• Mol File: 244218-93-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300 °C(Solv: ethanol (64-17-5))
• Boiling Point: 580.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.240±0.06 g/cm3(Predicted)
• PKA: 13.27±0.43(Predicted)
• CAS DataBase Reference: JTC-801(CAS DataBase Reference)
• NIST Chemistry Reference: JTC-801(244218-93-7)
• EPA Substance Registry System: JTC-801(244218-93-7)

Safety Data

• Hazardous Substances Data: 244218-93-7(Hazardous Substances Data)

Upstream product

• 5443-31-2 2-methyl-quinoline-4,6-diamine 
• 1025889-11-5 2-(4-ethyl-phenoxymethyl)-benzoyl chloride 
• 244219-98-5 methyl 2-[(4-ethylphenoxy)methyl]benzoate 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 89-71-4 2-Methyl-benzoic acid methyl ester 
• 100795-23-1 N-(4-methoxy-2-methyl-6-quinolyl)acetamide 
• 1140-81-4 N-(4-hydroxy-2-methylquinolin-6-yl)acetamide 
• 63304-46-1 N-(4-amino-2-methyl-quinolin-6-yl)-acetamide 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 244219-99-6 2-[(4-ethylphenoxy)methyl]benzoic acid 
• 17420-30-3 5-nitroanthranilonitrile 
• 99185-71-4 4-amino-2-methyl-6-nitroquinoline 

Relevant articles and documents

A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4- ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists

A series of 4-amino-2-methylquinoline and 4-aminoquinazoline derivatives, including the reference NOP antagonist JTC-801, were synthesized by an alternative pathway and their in vitro pharmacological properties were investigated. 3-Substitution of the qui

4-Aminoquinolines: Novel nociceptin antagonists with analgesic activity

Small-molecule nociceptin antagonists were synthesized to examine their therapeutic potential. After a 4-aminoquinoline derivative was found to bind with the human ORL1 receptor, a series of 4-aminoquinolines and related compounds were synthesized and their binding was evaluated. Elucidation of structure - Activity relationships eventually led to the optimum compounds. One of these compounds, N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide hydrochloride (11) not only antagonized nociceptin-induced allodynia in mice but also showed analgesic effect in a hot plate test using mice and in a formalin test using rats. Its analgesic effect was not antagonized by the opioid antagonist naloxone. These results indicate that this nociceptin antagonist has the potential to become a novel type of analgesic that differs from μ-opioid agonists.