244219-94-1

Basic information

• Product Name: 1-chloro-7-nitroisoquinoline
• Synonyms: 1-chloro-7-nitroisoquinoline
• CAS NO: 244219-94-1
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.6012
• Mol File: 244219-94-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-chloro-7-nitroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-7-nitroisoquinoline(244219-94-1)
• EPA Substance Registry System: 1-chloro-7-nitroisoquinoline(244219-94-1)

Safety Data

• Hazardous Substances Data: 244219-94-1(Hazardous Substances Data)

Usage

General Description

1-chloro-7-nitroisoquinoline is a chemical compound with the molecular formula C9H5ClN2O2 and a molar mass of 202.6 g/mol. It is a pale yellow solid that is insoluble in water but soluble in organic solvents. 1-chloro-7-nitroisoquinoline is used in the synthesis of various pharmaceutical compounds and is also employed as a reagent in organic chemical reactions. It is known to be a potent electrophilic aromatic substitute and is used in the preparation of a wide range of aromatic and heteroaromatic compounds. Additionally, it has been studied for its potential anti-tumor properties. However, due to its potential hazards, it should be handled with care and only used in a laboratory setting by trained professionals.

Upstream product

• 20141-83-7 7-nitroisoquinoline-1-ol 
• 82827-08-5 5-nitro-isoquinolin-1-ol 
• 309263-15-8 7-nitro-isoquinoline-2-oxide 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 13058-73-6 7-nitroisoquinoline 
• 42923-79-5 7-nitro-1,2,3,4-tetrahydroisoquinoline 
• 99365-69-2 7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 1975-52-6 5-nitro-o-toluic acid 
• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 1036388-63-2 (E)-methyl 2-(2-(dimethylamino)vinyl)-5-nitrobenzoate 
• 1036388-65-4 2-(2,4-dimethoxybenzyl)-7-nitroisoquinolin-1(2H)-one 

Downstream Products

• 98410-85-6 1-Amino-7-nitroisoquinoline 

Relevant articles and documents

Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors

The design, synthesis and biological evaluation of a series of isoquinoline-based hydroxamic acid compounds as novel HDACs inhibitors were reported herein. A detailed SAR study showed most of the compounds displayed good to excellent inhibitory activities against HDAC1, 3, 6. The IC50 values of compound 10c against HDAC1, 3, 6 were 4.17 ± 0.11 nM, 4.00 ± 0.10 nM, 3.77 ± 0.07 nM, respectively. Most of the compounds showed great anti-proliferative activities against RPMI 8226, HCT 116 and Hep G2 cells. The IC50 values of compounds 10a-h against RPMI 8226 cancer cell proliferation were all below 1 μM. HCT 116 cell was sensitive to the compounds 10a, 10f-g and 18a with the IC50 values 0.3 μM. The active compounds 10a-d did not show inhibitory activity against hERG channel. All these evidence indicated these compounds had great potential as HDACs inhibitors for the further development.

Synthesis and antimalarial activity of 7-benzylamino-1-isoquinolinamines

(Chemical Equation Presented) Computer modelling suggests that 7-benzylamino-1-isoquinolinamines should mediate antimalarial effects by a mechanism distinct from that employed by existing antimalarial drugs. A series of these compounds was prepared in sev

Amide derivatives and nociceptin antagonists

The present invention relates to a compound of the formula [1′] wherein R2is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.