244237-80-7Relevant academic research and scientific papers
Tin(IV) chloride promoted reaction of oxiranes with hydrogen peroxide
Yan, Xing,Qiao, Chunhua,Guo, Zhongwu
, p. 502 - 506 (2013/04/10)
A group of substituted oxiranes were readily transformed to the corresponding β-hydroxyhydroperoxides (HHP) in good yields in ethereal SnCl4-H2O2 system in which SnCl4 acts as catalyst. Alternatively, treating oxiranes with SnCl4 first, followed by addition of ethereal H2O2 solution achieved primary gem-dihydroperoxides (DHP) in moderate yields. In the case of preparing DHP, SnCl4 first promoted the rearrangement of oxiranes to aldehydes, followed by condensation with hydrogen peroxide to provide DHP as final products. Georg Thieme Verlag Stuttgart · New York.
A simple, efficient and versatile synthesis of primary gem-dihydroperoxides from aldehydes and hydrogen peroxide
Bunge, Alexander,Hamann, Hans-Jürgen,Liebscher, Jürgen
scheme or table, p. 524 - 526 (2009/04/14)
Aldehydes were efficiently converted directly into the corresponding gem-dihydroperoxides (DHPs) on treatment with aqueous 70% H2O2 in a biphasic system with ether catalyzed by camphorsulfonic acid. The synthesis represents the most versatile access to this class of compounds.
Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes
Kim,Nagai,Ono,Begum,Wataya,Hamada,Tsuchiya,Masuyama,Nojima,McCullough
, p. 2357 - 2361 (2007/10/03)
CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro[7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.
Synthetic methods for unsymmetrically-substituted 1,2,4,5-tetroxanes and of 1,2,4,5,7-pentoxocanes
Kim, Hye-Sook,Tsuchiya, Kaoru,Shibata, Yasuharu,Wataya, Yusuke,Ushigoe, Yoshihiro,Masuyama, Araki,Nojima, Masatomo,McCullough, Kevin J.
, p. 1867 - 1870 (2007/10/03)
Ozonolysis of vinyl ethers 1a-c in the presence of hydrogen peroxide in diethyl ether gave the corresponding 1,1-bis(hydroperoxide)s 2a-c. Subsequent trimethylsilylation, followed by the TMSOTf-catalyzed cyclocondensation with carbonyl compounds gave the
