244263-45-4

Usage

Uses

Used in Pharmaceutical Applications:
1-(6-Chloropyridin-3-yl)-2-methylpropan-1-one is utilized as an intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Research Applications:
In the research industry, 1-(6-Chloropyridin-3-yl)-2-methylpropan-1-one serves as a valuable chemical entity for studying its properties and reactions, which can lead to advancements in understanding organic chemistry and the discovery of novel chemical reactions or compounds.
Used in Organic Synthesis:
1-(6-Chloropyridin-3-yl)-2-methylpropan-1-one is employed as a building block in the production of a range of organic compounds, leveraging its unique structure to create new molecules with specific applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(6-Chloropyridin-3-yl)-2-methylpropan-1-one is used as a key component in the design and synthesis of new drug candidates, potentially leading to the development of innovative treatments for various diseases and conditions.

InChI:InChI=1/C9H10ClNO/c1-6(2)9(12)7-3-4-8(10)11-5-7/h3-6H,1-2H3

Upstream product

• 920-39-8 isopropylmagnesium bromide 
• 149281-42-5 6-chloro-N-methoxy-N-methylpyridine-3-carboxamide 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 1068-55-9 isopropylmagnesium chloride 

Relevant academic research and scientific papers

A concise route to novel 1-aryl and 1-pyridyl-2-azabicyclo[2.1.1]hexanes

A number of novel 1-aryl and 1-pyridyl-2-azabicyclo[2.1.1]hexane derivatives were prepared by an intramolecular [2+2] photocycloaddition in the presence of acetophenone as the sensitizer. Substitution of the azabicyclo[2.1.1]hexane ring was accomplished by appropriate choice of the heteroaryl ketone and allylamine starting materials. Several aryl 9a-e, g and pyridyl analogs 9h-l were prepared by this method. The structures of 9a and 9i were verified by X-ray crystallography. Several of the photoproducts 9 were converted into the corresponding N-Me and N-H 2,4-methanonicotine analogs 4 by reduction or hydrolysis of the N-carboethoxy group.

SPIRO-THIAZOLONES

The present invention provides spiro-thiazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, aggressive behavior and phase shift sleep disorders, in particular jetlag.

Addition of Grignard reagents to aryl acid chlorides: An efficient synthesis of aryl ketones

(Chemical Equation Presented) Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nucleophilic addition by Grignard reagents.