244307-08-2

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 80971-33-1 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine 
• 563-41-7 semicarbazide hydrochloride 
• 242475-43-0 5'-O-4,4'-dimethoxytrityl-3'-O-tertbutyldimethylsilyl-4-O-triisopropylphenylsulfonyl thymidine 

Downstream Products

• 244307-10-6 N⁴-ureido-5'-O-4,4'-dimethoxytrityl-5-methyl-2'-deoxycytidine 

Relevant academic research and scientific papers

Synthesis and triplex forming properties of pyrimidine derivative containing extended functionality

Two pyrimidine nucleosides have been synthesized containing extended hydrogen bonding functionality. In one case the side chain is based upon semicarbazide and in the second monoacetylated carbohydrazide was employed. DNA sequences could be prepared using both analogue nucleosides in a reverse coupling protocol, and provided that the normals capping step was eliminated and that the iodine-based oxidizing solution was replaced with one based upon 10-camphorsulfonyl oxaziridine. Both derivatives exhibited moderate effects in targeting selectively C-G base pairs embedded within a polypurine target sequences.