24442-03-3

Upstream product

• 13226-93-2 ethyl 3-phenylpropanimidate 
• 645-59-0 dihydrocinnamonitrile 

Downstream Products

• 892592-59-5 6-ethyl-3-(2-phenylethyl)-1,2,4-triazin-5(2H)-one 
• 1542166-99-3 4-(tert-butyl) 6-ethyl 5-methyl-2-phenethylpyrimidine-4,6-dicarboxylate 
• 1542167-00-9 4-(tert-butyl) 6-ethyl 2-phenethylpyrimidine-4,6-dicarboxylate 
• 1417818-03-1 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one 
• 1417817-39-0 5-hydroxy-2-(2-phenylethyl)pyrimidin-4(3H)-one 
• 1313511-95-3 C₁₂H₁₂N₂O₂ 
• 1186308-90-6 C₂₅H₂₁FN₂O₂S 

Relevant academic research and scientific papers

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors

Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: A novel class of selective human A-FABP inhibitors

The synthesis and evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.