24442-56-6Relevant academic research and scientific papers
Substrate-Controlled Product Divergence: Conversion of CO2 into Heterocyclic Products
Rintjema, Jeroen,Epping, Roel,Fiorani, Giulia,Martín, Eddy,Escudero-Adán, Eduardo C.,Kleij, Arjan W.
, p. 3972 - 3976 (2016)
Substituted epoxy alcohols and amines allow substrate-controlled conversion of CO2 into a wide range of heterocyclic structures through different mechanistic manifolds. This new approach results in an unusual scope of CO2-derived products by initial activation of CO2 through either the amine or alcohol unit, thus providing nucleophiles for intramolecular epoxy ring opening under mild reaction conditions. Control experiments support the crucial role of the amine/alcohol fragment in this process with the nucleophile-assisted ring-opening step following an SNi pathway, and a 5-exo-tet cyclization, thus leading to heterocyclic scaffolds.
Synthesis of spirocyclic ethers by radical cyclization of epoxides using a transition-metal radical source
Rana,Guin,Roy
, p. 925 - 929 (2007/10/03)
A series of spirocyclic ethers, possible versatile intermediates towards naturally occurring compounds, have been synthesized by radical cyclization of epoxides. The carbon-centered radical from an epoxide is generated by using a Ti(III) radical initiator.
