24447-14-1Relevant academic research and scientific papers
Improved synthesis of oxadiazoles under microwave irradiation
Oussaid,Moeini,Martin,Villemin,Garrigues
, p. 1451 - 1459 (1995)
Amidoximes reacted with isopropenyl acetate in presence of KSF under microwave irradiation and gave 1,2,4-oxadiazoles. 1,2,4-Oxadiazoles can also be obtained by microwave irradiation from O-acetylamidoximes absorbed on Alumina. 1,3,4-Oxadiazoles were obta
Synthesis method of 2,5-disubstituted-1,3,4-oxadiazole
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Paragraph 0007; 0032, (2018/08/04)
The invention discloses a synthesis method of a drug intermediate, namely, 2,5-disubstituted-1,3,4-oxadiazole. 2,5-disubstituted-1,3,4-oxadiazole is synthesized with a one-pot method under the photocatalytic action with simple hydrazide compounds as raw materials. 2,5-disubstituted-1,3,4-oxadiazole can be produced through a reaction at the room temperature with a common halogen lamp as a light source, eosinY as a catalyst, potassium carbonate as an additive and ethanol as a solvent. The method has the characteristics that the raw material source is simple, the reaction condition is mild and the like.
A new synthesis of symmetrical 2,5-disubstituted 1,3,4- oxadiazoles
Bentiss, Fouad,Lagrenee, Michel
, p. 1029 - 1032 (2007/10/03)
Several new 2,5-disubstituted 1,3,4-oxadiazoles have been synthesized in good yields by reaction of aromatic acids with hydrazine dihydrochloride in a mixture of orthophosphoric acid, phosphorus pentoxide and, in general, with addition of phosphorus oxychloride to the reaction mixture. The structures of new oxadiazoles derivatives were confirmed by analytical and spectral data.
SYNTHESE D'OXADIAZOLES ET D'OXAZOLES THIOPHENIQUES
Oussaid, Boualem,Moeini, Leila,Garrigues, Bernard,Villemin, Didier
, p. 23 - 30 (2007/10/02)
Some potentially active drugs: oxadiazoles (4, 8, 17), oxazoles (10, 12a, 12b, 13) heterocycles substituted by a thiophenic moiety have been prepared by a multistep procedure. Key words: Thiophene; oxadiazole; oxazole; potentially active drugs.
Unusual Rearrangement in the Dehydration of Aroylated Butanodihydrazides
Tashtoush, Hasan,Al-Talib, Mahmoud,Odeh, Nedal
, p. 291 - 292 (2007/10/02)
Dehydration of N,N'-diaroylbutanodihydrazides 3a-f with phosphoryl chloride gave, unexpectedly, 2,5-diaryl-1,3,4-oxadiazoles 4a-f.However, dehydration of N,N'-dialkanoylbutanodihydrazides 1a-c afforded 5,5'-dialkyl-2,2'-(ethandiyl)-bis(1,3,4-oxadiazoles) 2a-c. Key Words: 1,3,4-Oxadiazole / Butanodihydrazides
N,N-Dimethylchlorosulfitemethaniminium chloride as a dehydrating agent - An efficient one-pot synthesis of 1,3,4-oxadiazoles and 4H-3,1-benzoxazin-4-ones
Sain, Bir,Sandhu, Jagir S
, p. 768 - 770 (2007/10/02)
Aroylhydrazines (3) on treatment with carboxylic acids (1) in the presence of N,N-dimethylchlorosulfitemethaniminium chloride (2) yields directly 1,3,4-oxadiazoles (4).Reaction between anthranilic acid (6) and carboxylic acids (5) in the presence of 2 affords 4H-3,1-benzoxazin-4-ones (7).
