24451-12-5

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 2735-04-8 2,4-Dimethoxyaniline 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 92643-74-8 ethyl N-(2,4-dimethoxy-5-nitrophenyl)oxanilate 
• 1158560-11-2 N-(2,4-dimethoxyphenyl)-2-(4-morpholinyl)-2-oxoacetamide 
• 92643-76-0 diethyl 4,6-dimethoxy-1,3-phenylenediiminobis(oxoacetate) 
• 92643-77-1 4,6-dihydroxy-1,3-phenylenediiminobis(oxoacetic acid) 
• 92643-75-9 ethyl N-(2,4-dimethoxy-5-aminophenyl)oxanilate 
• 22505-18-6 N-(5-tert-Butyl-2-octyloxy-phenyl)-N'-(2,4-dimethoxy-phenyl)-oxalamide 
• 22505-17-5 N-(5-tert-Butyl-2-methoxy-phenyl)-N'-(2,4-dimethoxy-phenyl)-oxalamide 

Relevant academic research and scientific papers

Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions

Herein, we describe the development of copper-catalyzed cross-coupling of DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect the transformation in aqueous D

A new approach to methoxyisatins leading to the total synthesis of ophiuroidine and other hydroxytryptanthrins

A new method for the preparation of methoxyisatins from the corresponding methoxyanilines is described. The resulting methoxyisatins were used in the syntheses of several methoxytryptanthrin compounds. The natural product ophiuroidine (4,8,9-trihydroxytry

Synthesis and quantitative structure-activity relationships of oxanilates as chemical hybridizing agents for wheat (Triticum aestivum L.)

Chemical hybridizing agents (CHAs) can facilitate two-line breeding in heterosis programs of crops. Twenty-seven oxanilates having different aromatic substitutions were synthesized and screened as CHAs on two genotypes of wheat, PBW 343 and HD 2733, during two Rabi (winter) seasons, 2000-01 and 2001-02. The oxanilates prepared by thermal condensation of anilines with diethyl oxalate or by acylation with ethoxycarbonyl methanoyl chloride were sprayed at 1000 and 1500 ppm at the premeiotic stage of wheat, when the length of the emerging spike of the first node was 7-8 mm. Pollen sterility and spikelet sterility were measured in each treatment. Ethyl oxanilates 5, 6, and 25, containing 4-F, 4-Br, and 4-CF3 aromatic substituents, respectively, induced greater than 98% spikelet sterility, the desired level, at 1500 ppm. Quantitative structure-activity relationship analysis revealed a direct relationship between Fp and molecular mass but an inverse relationship between MR, Es, and R in influencing the bioactivity. Several F1 hybrids were developed using 5, and at least one showed heterosis.

Evaluation of DIMBOA analogs as antifeedants and antibiotics towards the aphid Sitobion avenae in artificial diets

A total of 25 compounds including benzoxazinones, benzoxazolinones, and N-glyoxylamide derivatives were tested as antifeedants and antibiotics towards the aphid Sitobion avenae in diet bioassays. The antifeedant and mortality indexes increased with the presence of electron-donating groups in the 7 position of the benzoxazinone moiety, the replacement of the oxygen atom by sulfur in the heterocyclic ring, the presence of a hemiacetal instead of an acetal at C-2 of the benzoxazine moiety (and hence the possibility of ring opening), and the presence of a hydroxyl group at C-4 of the benzoxazine moiety (hydroxamic acid) instead of a hydrogen atom (lactam). The results support earlier hypotheses on the chemical bases for the mode of action of these compounds.

Benzoxazine-2,3-diones as Antiallergic Agents

The synthesis of a series of benzoxazine-2,3-diones and a new class of compounds, benzobisoxazinetetrones, is described.These compounds were evaluated for their effect in the rat mast cell (RMC) test passively sensitized in vitro with rat antiovalbumin serum and for their effect in inhibitory passive cutaneous anaphylaxis (PCA) in the rat.Some of this compounds are of the same potency level as disodium cromglycate in the RMC test and some are effective orally in PCA.