24457-00-9Relevant articles and documents
Transformations of S-substituted 5,7-dimethyl-4а,5а-diphenyl-3-thioxoperhydroimidazo[4,5-e]-1,2,4-triazin-2-ones under treatment of 1,2-benzoquinones and photochemical properties of reaction products
Kravchenko, Angelina N.,Vasilevskii, Sergei V.,Gazieva, Galina A.,Baranov, Vladimir V.,Barachevsky, Valery A.,Kobeleva, Olga I.,Venidiktova, Olga V.,Karnoukhova, Valentina A.
, p. 2359 - 2368 (2018/04/09)
For the first time 5,7-di-tert-butyl-1,3-dimethyl-3a,9a-diphenyl-3,3a-dihydro-1H-benzo[5,6][1,4]dioxino[2,3-d]imidazol-2(9aH)-one 13 and complex 9 of 4,6-di-tert-butyl-3-nitrobenzene-1,2-diol with 1,3-dimethyl-4,5-diphenyl-1H-imidazol-2(3H)-one 10a were p
Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
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Paragraph 0563, (2015/09/22)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
Unexpected formation of 6-[benzofuran-3(2H)-ylidene]-3,3a,9,9a-tetra- hydroimidazo[4,5-e]thiazolo[3,2-b][1,2,4]triazine-2,7-dione derivative
Kravchenko, Angelina N.,Vasilevskii, Sergei V.,Gazieva, Galina A.,Nelyubina, Yulia V.
, p. 476 - 478 (2015/12/30)
Condensation of 4,6-di(tert-butyl)-3-nitro-1,2-benzoquinone with 1,3-dimethyl-3a,9a-diphenyl-3,3a,9,9a-tetrahydroimidazo[4,5-e]- thiazolo[3,2-b][1,2,4]triazine-2,7(1H,6H)-dione in AcOH gives a new 6-(benzofuranylidene)tetrahydroimidazo[4,5-e]thiazolo[3,2-
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
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, (2012/12/14)
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
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, (2012/04/23)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.