244609-83-4Relevant academic research and scientific papers
β-Carbolinedione derivatives as topoisomerase I inhibitors
Mahboobi, Siavosh,Eluwa, Stella,Sunil Kumar,Koller, Markus,Stoerl, Karin
, p. 249 - 254 (2007/10/03)
Pyrrolo[3,4-c]-β-carbolinedione dimers 5-14 were synthesized from furo[3,4-c]-β-carbolinediones and diamines by solvent-free TaCl5/silica catalyzed reaction under microwave irradiation. The inhibitory property of these target-compounds, the starting materials 2, 31, 32, and the N-alkylated pyrrolo[3,4-c]-β-carbolinediones 16, 17, 20-30 was tested against the relaxation of supercoiled pRB322 DNA by calf thymus topoisomerases I and II. Some of these compounds, especially 7 and 23 proved to be selective inhibitors of topoisomerase I.
