24463-56-7

Upstream product

• 288-88-0 1,2,4-Triazole 
• 75-30-9 2-iodo-propane 

Downstream Products

• 1448427-99-3 6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine 
• 1448428-04-3 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide 

Relevant academic research and scientific papers

An investigation into the alkylation of 1,2,4-triazole

The alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Previously reported regiospecific alkylations of 1,2,4-triazole were re-examined and the quoted isomer ratios were shown to depend on the isolation procedure. The use of DBU as base in the alkylation of 1,2,4-triazole allows for a convenient and high yielding synthesis of 1- substituted-1,2,4-triazoles. (C) 2000 Elsevier Science Ltd.

1,2,4-4H-triazole derivatives

Substituted 1,2,4-4H-triazoles of the formula STR1 wherein A is a variety of groups including alkyl, --C(O)R4, --CH(OH)CCl3 and substituted benzyl and phenyl and R8 is alkyl. These compounds are fungicides and are particularly useful for the control of cereal rusts.