244633-31-6

Basic information

• Product Name: 2,3,4,5,6-PENTAFLUOROPHENYL 4-NITROBENZENESULFONATE
• Synonyms: 2,3,4,5,6-PENTAFLUOROPHENYL 4-NITROBENZENESULFONATE;pentafluorophenyl 4-nitrobenzenesulfonate;4-Nitrobenzenesulfonic acid pentafluorophenyl ester;Pentafluorophenyl 4-nitrobenzenesulfonate≥ 98%(GC)
• CAS NO: 244633-31-6
• Molecular Formula: C₁₂H₄F₅NO₅S
• Molecular Weight: 369.22
• Mol File: 244633-31-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 109-111°C
• Boiling Point: 438.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.709±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: soluble in Toluene
• CAS DataBase Reference: 2,3,4,5,6-PENTAFLUOROPHENYL 4-NITROBENZENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5,6-PENTAFLUOROPHENYL 4-NITROBENZENESULFONATE(244633-31-6)
• EPA Substance Registry System: 2,3,4,5,6-PENTAFLUOROPHENYL 4-NITROBENZENESULFONATE(244633-31-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 244633-31-6(Hazardous Substances Data)

Usage

Chemical Properties

White to pale yellow crystalline powder

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 30362-87-9 p-Nitrophenyl p-nitrobenzenesulphonate 
• 26910-95-2 pentafluorophenolate anion 

Downstream Products

• 86060-85-7 Fmoc-Gly-OPfp 
• 86060-87-9 Fmoc-Val-OPfp 
• 959-22-8 p-nitrophenylbenzoate 
• 244633-35-0 3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid pentafluorophenyl ester 
• 86060-94-8 N-α-Fmoc-L-methionine pentafluorophenyl ester 
• 86060-98-2 Fmoc-L-Lys(Boc)-OPfp 
• 86061-04-3 N^α-Fmoc-Glu-(O-tBu)-OPfp 
• 105751-13-1 O-tert-butyl-N^α-(fluoren-9-ylmethoxycarbonyl)-L-serine pentafluorophenyl ester 
• 86060-92-6 N-α-Fmoc-L-phenylalanine pentafluorophenyl ester 
• 50903-50-9 N-[(1,1-dimethylethoxy)carbonyl]-L-leucine pentafluorophenyl ester 
• 50903-47-4 perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate 

Relevant articles and documents

Pentafluorophenyl 4-nitrobenzenesulfonate as a peptide coupling reagent

Protected dipeptides were obtained in good yield by coupling Boc- or Fmoc-protected amino acids with amino acid esters in the presence of pentafluorophenyl 4-nitrobenzenesulfonate (PFNB) as peptide coupling agent and 1-hydroxybenzotriazole as catalyst.

Synthesis of aryl esters of protected amino acids from aryl sulfonates

Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.