244633-46-3Relevant academic research and scientific papers
Enantioselective synthesis of quaternary stereocenters via a catalytic asymmetric stetter reaction
Kerr, Mark S.,Rovis, Tomislav
, p. 8876 - 8877 (2004)
A new electron-deficient chiral triazolium salt has been shown to catalyze the formation of quaternary stereocenters by an asymmetric intramolecular Stetter reaction. Pentafluorophenyl substitution on an aminoindanol-derived catalyst affords tertiary ether, thioether, and quaternary stereocenters in typically greater than 90% ee and very good chemical yield. Aromatic and aliphatic aldehydes are equally competent substrates for this reaction. The reaction proceeds at room temperature under mild conditions to provide quaternary stereocenters with functional group relationships that are particularly difficult to access by other methods. Copyright
Enantioselective formation of quaternary stereocenters using the catalytic intramolecular Stetter reaction
Moore, Jennifer L.,Kerr, Mark S.,Rovis, Tomislav
, p. 11477 - 11482 (2007/10/03)
Asymmetric formation of quaternary stereocenters has been accomplished using the catalytic intramolecular Stetter reaction. A?variety of tethered aldehydes and Michael acceptors are cyclized in excellent yields and enantioselectivities.
Enantioselective alkylations of tributyltin enolates catalyzed by Cr(salen)CI: Access to enantiomerically enriched all-carbon quaternary centers
Doyle, Abigail G.,Jacobsen, Eric N.
, p. 62 - 63 (2007/10/03)
The catalytic asymmetric α-alkylation of tributyltin enolates with a range of primary alkyl halides is catalyzed by a chiral Cr(salen) complex. The reaction constitutes the first transition-metal-catalyzed system for α-alkylation of carbonyl substrates wi
Nitroalkenes as electrophiles in the asymmetric Michael reaction involving chiral imines/enamino esters
Thominiaux, Cyrille,Rousse, Sebastien,Desmaele, Didier,D'Angelo, Jean,Riche, Claude
, p. 2015 - 2021 (2007/10/03)
Addition of 2-nitropropene to the chiral imine derived from 2- methylcyclopentanone and (S)-1-phenylethylamine furnished the expected Michael adduct. The latter compound was then efficiently converted into (R)- pentalenone through a Nef reaction. Condensa
