244642-02-2Relevant academic research and scientific papers
Novel benzyl rearrangements in electrospray ionization multistage tandem mass spectra of benzyl 2',3'- didehydro-2',3'-dideoxythymidin-5'-yl H-phosphonate.
Chen,Sun, Xiaobin,Fu, Hua,Liu, Xiaohong,Zhao, Yufen
, p. 730 - 735 (2004)
Several alkyl 2',3'-didehydro-2',3'-dideoxythymidin-5'-yl H-phosphonates were synthesized and analyzed by electrospray ionization multistage tandem mass spectrometry (ESI-MS(n)). Two kinds of novel benzyl rearrangement reactions were observed in ESI - MS(
Synthesis of AZT/d4T boranophosphates as anti-HIV prodrug candidates
Lin, Changxue,Fu, Hua,Tu, Guangzhong,Zhao, Yufen
, p. 509 - 516 (2007/10/03)
AZT/d4T phosphonates were synthesized by sequential condensation of AZT/ d4T with the corresponding alcohols or 5′-DMT-thymidine in the presence of pivaloyl chloride. Sequential silylation, boronation, and hydrolysis in ammonium hydroxide of these phosphonates led to anti-HIV prodrug candidates AZT/d4T boranophosphates.
One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT.
Sun, Xiao Bin,Kang, Jian Xun,Zhao, Yu Fen
, p. 2414 - 2415 (2007/10/03)
A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.
