244759-17-9Relevant academic research and scientific papers
Benzimidazole cyclooxygenase-2 inhibitors
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, (2008/06/13)
This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof, wherein Ar is heteroaryl; X1and X2are independently selected from halo, C1-C4alkyl, hydroxy, C1-C4alkoxy, amino, C1-C4alkanoyl, carboxy, carbamoyl, cyano, nitro, mercapto, (C1-C4alkyl)thio, (C1-C4alkyl)sulfinyl, (C1-C4alkyl)sulfonyl, aminosulfonyl, or the like; R1is selected from hydrogen, straight or branched C1-C4alkyl, C3-C8cycloalkyl, C4-C8cycloalkenyl, phenyl , heteroaryl and the like; R2and R3are independently selected from hydrogen, halo, C1-C4alkyl, phenyl and the like; or R1and R2can form, together with the carbon atom to which they are attached, a C5-C7cycloalkyl ring; and m and n are independently 0, 1, 2 or 3. These compounds and pharmaceutical compositions containing such compounds are useful as analgesics and anti-inflammatory agents.
