244759-45-3

Basic information

• Product Name: (2E)-3-(4-isopropylphenyl)acryloyl chloride
• Synonyms: (E)-3-(4-isopropylphenyl)acryloyl chloride;(2E)-3-(4-isopropylphenyl)acryloyl chloride;(E)-3-(4-isopropylphenyl)prop-2-enoyl chloride;(E)-3-(4-propan-2-ylphenyl)prop-2-enoyl chloride;2-propenoyl chloride, 3-[4-(1-methylethyl)phenyl]-, (2E)-
• CAS NO: 244759-45-3
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.68
• Mol File: 244759-45-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(4-isopropylphenyl)acryloyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(4-isopropylphenyl)acryloyl chloride(244759-45-3)
• EPA Substance Registry System: (2E)-3-(4-isopropylphenyl)acryloyl chloride(244759-45-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 244759-45-3(Hazardous Substances Data)

Upstream product

• 3368-21-6 4-isopropylcinnamic acid 
• 3368-21-6 (E)-4-isopropylcinnamic acid 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 934192-41-3 dithiocarbonic acid S-[3-(acetyl-allyl-amino)-1-(4-isopropyl-phenyl)-3-oxo-propyl] ester O-ethyl ester 
• 99564-72-4 (E)-3-(4-isopropylphenyl)acrylamide 

Relevant articles and documents

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

Chikungunya virus is a re-emerging arbovirus transmitted to humans by Aedes mosquitoes, responsible for an acute febrile illness associated with painful and debilitating arthralgia, which can persist for several months or become chronic. Over the past few years, infection with this virus has spread worldwide with a previously unknown virulence. No specific antiviral treatments nor vaccines are currently available against this important pathogen. Starting from the structure of a class of selective anti-CHIKV agents previously identified in our research group, different modifications to this scaffold were rationally designed, and 69 novel small-molecule derivatives were synthesised and evaluated for their inhibition of Chikungunya virus replication in Vero cells. Further structure-activity relationships associated with this class of antiviral agents were elucidated for the original scaffolds, and novel antiviral compounds with EC50 values in the low micromolar range were identified. This work provides the foundation for further investigation of these new structures as antivirals against Chikungunya virus.

Synthesis and biological evaluation of N-cinnamoyl and mandelate metformin analogues

A series of N,N-dimethyl-N1-[3-(substituted phenyl)-1-oxo-2-propenyl]biguanides were synthesized by coupling a solution of metformin in pyridine with different cinnamoyl chloride derivatives in ether for 3 h in addition to synthesis of some five molecules of metformin-mandelates. All the synthesized cinnamoyl metformins and a few metformin-mandelates were characterized by IR, NMR and Mass spectroscopic techniques. All the synthesized compounds were also evaluated for their antioxidant activity by DPPH scavenging method and nitric oxide scavenging method. All the compounds exhibited good antioxidant activity.

Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones

We recently described two novel aryl binding sites of farnesyltransferase. In this study, the cinnamoyl residue was designed as an appropriate substituent for our benzophenone-based AAX-peptidomimetic compound capable of occupying the far aryl binding site.