244770-99-8Relevant articles and documents
New syntheses of the benzoquinone primin and its water-soluble analog primin acid via Heck reactions
Mabic,Vaysse,Benezra,Lepoittevin
, p. 1127 - 1134 (2007/10/03)
The syntheses of primin, 2-methoxy-6-pentylbenzoquinone (1), a major allergen of Primula obconica, and its water-soluble acid analog primin acid (2) are reported. The key steps were ortho-lithiation reactions of protected hydroquinones, palladium coupling (Heck) reactions, and salcomine-catalyzed oxidations of phenols to quinones.