244785-25-9Relevant academic research and scientific papers
Regiocontrolled synthesis of carbocycle-fused indoles via arylation of siyl enol ethers with o-nitrophenylphenyliodonium fluoride
Iwama, Tetsuo,Birman, Vladimir B.,Kozmin, Sergey A.,Rawal, Viresh H.
, p. 673 - 676 (2008/02/12)
(Matrix presented) A new, regiocontrolled synthesis of carbocycle-fused indoles has been developed. The two-step procedure involves first the regiospecific arylation of silyl enol ethers with o-nitrophenylphenyliodonium fluoride (1). Reduction of the nitro group on the aromatic ring with TiCl3 followed by spontaneous condensation of the aniline with the ketone then affords the indole products.
