2448-68-2

Basic information

• Product Name: 1'-[4-(4-fluorophenyl)-4-oxobutyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride
• Synonyms: Pipamperone hydrochloride;R4050, 1μ-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4μ-bipiperidine]-4μ-carboxamide dihydrochloride;Nsc170981;Pipamperone DiHCl
• CAS NO: 2448-68-2
• Molecular Formula: C21H30FN3O2.2ClH
• Molecular Weight: 448.46
• EINECS: 219-507-5
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 2448-68-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 203-218°C
• Boiling Point: 563.7°Cat760mmHg
• Flash Point: 294.7°C
• Appearance: white/
• Density: g/cm³
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: H2O: ~50mg/mL
• CAS DataBase Reference: 1'-[4-(4-fluorophenyl)-4-oxobutyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-[4-(4-fluorophenyl)-4-oxobutyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride(2448-68-2)
• EPA Substance Registry System: 1'-[4-(4-fluorophenyl)-4-oxobutyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride(2448-68-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 1
• RTECS: DW1060000
• Hazardous Substances Data: 2448-68-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 2448-68-2 differently. You can refer to the following data:
1. Pipamperone dihydrochloride may be used: as an internal standard in liquid chromatography with coulometric detectionas an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channelas an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis
2. Antipsychotic.

Definition

ChEBI: A hydrochloride resulting from the reaction of pipamperone with 2 mol eq. of hydrogen chloride. It is used as an antipsychotic.

Biochem/physiol Actions

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.