24503-35-3

Upstream product

• 103-65-1 phenylpropane 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 42411-95-0 4-propyl-3-nitroaniline 
• 72635-75-7 5-nitro-2-propyl-aniline 
• 27581-20-0 2-n-propyl-5-chlorophenol 
• 56152-26-2 5-Brom-2-propyl-phenol 
• 90942-41-9 2-Propyl-5-chlor-1-nitro-benzol 
• 3355-08-6 4-Bromo-2-nitro-1-propyl-benzene 
• 90415-69-3 5-chloro-2-propylphenylamine 
• 3355-21-3 5-Bromo-2-propyl-phenylamine 
• 93897-53-1 <5-Chlor-2-propyl-phenyl>-4-brom-benzolsulfonat 
• 92425-68-8 <5-Brom-2-propyl-phenyl>-4-brom-benzolsulfonat 
• 873056-02-1 (3-amino-4-propylphenyl)-methyl-carbamic acid tert-butyl ester 
• 873056-01-0 methyl-(3-nitro-4-propylphenyl)carbamic acid tert-butyl ester 
• 873056-00-9 (3-nitro-4-propylphenyl)carbamic acid tert-butyl ester 
• 94-73-5 2,4-diamino-1-n-propylbenzene 

Relevant academic research and scientific papers

NEW COMPOUND

PROBLEM TO BE SOLVED: To provide a new compound that does not have structural similarity to ceramide and has excellent CERT inhibitory activity. SOLUTION: The present invention provides a new compound of structural formula (I). A bond group -X- is cis-cyclopropyl-, R1, R2, R3, R4, and R5 independently represent a hydrogen atom, a halogen atom, a linear or branched C1-C8 alkyl group that may have a halogen atom, or OR6. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Regioselective dinitration of simple aromatics over zeolite Hβ/nitric acid/acid anhydride systems

Various nitration systems comprising nitric acid, acid anhydride and zeolite H￡] in the absence of solvent are described. Direct double nitration of toluene with a nitric acid, propanoic anhydride and zeolite Hβ system has been developed to give 2,4-dinitrotoluene in 98% yield, with a 2,4-:2,6-dinitrotoluene ratio of 123:1. This system also nitrates activated mono-substituted benzenes (anisole and phenetole) and moderately activated mono-substituted benzenes (ethylbenzene and propylbenzene) to give mainly 2,4-dinitro derivatives. The zeolite can be recovered, regenerated and reused to give almost the same yield as that given when fresh zeolite is used. ARKAT-USA, Inc.

Highly regioselective dinitration of toluene over reusable zeolite Hβ

A nitration system comprising nitric acid, propanoic anhydride, and zeolite Hβ has been developed for dinitration of toluene to give 2,4-dinitrotoluene in 98% yield, with a 2,4-:2,6-dinitrotoluene ratio of over 120. This represents the most selective quantitative method for 2,4-dinitration of toluene; the catalyst is reusable, solvent is not needed, and an aqueous work-up is not required.

METHODS FOR THE NITRATION OF AROMATIC COMPOUNDS

According to the invention there is provided a method for the nitration of an aromatic compound including the step of reacting the aromatic compound with nitric acid in the presence of an acid anhydride and an aluminosilicate catalyst, in which the acid anhydride is at least one of: ((CnH2n+1)CO)20, where n is 1 to 4 and the moiety CnH2n+1 can be straight or branched chain; ((CHpClq)CO)20, where p is 0 to 2, q is 1 to 3, and p+q = 3; and oxoiane -2, 5-dione, with the proviso that when the acid anhydride is (CH3CO)20, the aromatic compound is toluene, 2-nitrotoluene or 4-nitrotoluene, and the nitration is performed to produce 2,4-dinitrotoluene.