245037-98-3Relevant academic research and scientific papers
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists
Gillman, Kevin W.,Higgins, Mendi A.,Poindexter, Graham S.,Browning, Marc,Clarke, Wendy J.,Flowers, Sharon,Grace Jr., James E.,Hogan, John B.,McGovern, Rachel T.,Iben, Lawrence G.,Mattson, Gail K.,Ortiz, Astrid,Rassnick, Stefanie,Russell, John W.,Antal-Zimanyi, Ildiko
, p. 5517 - 5526 (2007/10/03)
A series of novel 5,5-diphenylimidazolones was synthesized and evaluated for activity against the human neuropeptide Y5 receptor. The 3-pyridyl analog 46 demonstrated an IC50 of 8.3 nM with a favorable pharmacokinetic profile in rats, but was i
Imidazolone anorectic agents: II. phenyl derivatives
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, (2008/06/13)
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
