245092-64-2

Upstream product

• 10285-80-0 N-tosyl-3-butenylamine 
• 4028-23-3 Allylchlorodimethylsilane 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 

Downstream Products

• 245092-73-3 1-[1-(toluene-4-sulfonyl)piperidin-2-yl]pentan-2-ol 
• 245092-67-5 1-[1-(toluene-4-sulfonyl)-1,2,5,6-tetrahydropyridin-2-yl]pent-4-en-2-ol 
• 26648-71-5 (-)-halosaline 
• 245092-65-3 (S)-6-((S)-2,2-Dimethyl-3,6-dihydro-2H-[1,2]oxasilin-6-ylmethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Total synthesis of (-)-halosaline by a ruthenium-catalyzed ring rearrangement

The stereoselective synthesis of substituted piperidines by a ruthenium- catalyzed ring rearrangement of cyclopentene derivatives is demonstrated. The influence of different substituents and the effect of ethylene on the metathesis reaction is described. The ring rearrangement can be combined with a molybdenum-catalyzed cross metathesis reaction using allyltrimethyl silane as coupling partner. The first total synthesis of (-)-halosaline was accomplished via domino metathesis reaction utilizing Grubbs' ruthenium catalyst.