245116-64-7

Upstream product

• 245116-61-4 4-(1,1-Dimethoxyethyl)-2,5-dipropoxyacetophenon 
• 245116-63-6 (E)-2,5-Dipropoxy-4-[3-(2,5-dipropoxyphenyl)-3-oxopropenyl]benzaldehyd 
• 245116-60-3 1-Brom-4-(1,1-dimethoxyethyl)-2,5-dipropoxybenzol 
• 245116-58-9 4-Dimethoxymethyl-2,5-dipropoxybenzaldehyd 
• 243970-10-7 1-Brom-4-dimethoxymethyl-2,5-dipropoxybenzol 
• 142499-42-1 2',5'-Dipropoxyacetophenon 

Downstream Products

• 245116-68-1 H(C₆H₂(OC₃H₇)2COCHCHC₆H₂(OC₃H₇)2CHCHCO)3C₆H₃(OC₃H₇)2 
• 245116-65-8 (E,E,E)-4-{3-{2,5-Dipropoxy-4-{3-{2,5-dipropoxy-4-[3-(2,5-dipropoxyphenyl)-3-oxopropenyl]phenyl}propenoyl}phenyl}-3-oxopropenyl}-2,5-dipropoxybenzaldehyd 

Relevant academic research and scientific papers

Oligomers of Alternately Arranged Chalcone Building Blocks

The cross-conjugated oligomers 1a-d, which contain up to eight alternately arranged chalcone building blocks, were prepared by stereoselective condensation reactions of formyl and acetyl components. The synthetic sequence started with 1,4-dibromo-2,5-dipropoxybenzene (2). Bouveault reactions with DMF and DMA yielded the aldehydes 3 and 6 and the ketones 7 and 10. After the protection of the carbonyl group (3 → 4 and 7 → 8), a further Bouveault reaction led to monoprotected dialdehyd 5 and dike-tone 9, respectively. Repetitive condensation reactions starting with the acetophenone derivative 11 and 5 furnished the aldehyde 12, the ketone 13 and the aldehyde 14. In the final step the target compounds 1 were obtained again by condensation reactions: 6 + 11 → 1a, 10 + 12 → 1b, 6 + 13 → 1c, 10 + 14 → 1d. Thus a convergent and coupled synthesis was achieved in order to generate constitutionally and configurationally pure oligochalcones.