24512-60-5 Usage
Chemical structure
A bufadienolide compound with a unique arrangement of functional groups, including a 16β-acetyloxy group, a 14,15β-epoxy group, and a 3β,5-dihydroxy group.
Source
Found in the skin and parotid venom glands of the Asiatic toad, Bufo gargarizans cantor.
Traditional use
Used in Chinese medicine for its cardiotonic and anti-inflammatory properties.
Anti-cancer potential
Studied for its potential anti-cancer effects, including the ability to inhibit the growth of tumor cells and induce apoptosis.
Anti-inflammatory effects
Investigated for its potential to reduce inflammation and alleviate symptoms of inflammatory conditions.
Cardiac effects
Known for its cardiotonic properties, which can help strengthen the heart muscle and improve heart function.
Toxicity
Highly toxic and can cause severe cardiac toxicity if not used properly.
Safety precautions
Should be used with caution and under the supervision of a qualified healthcare professional due to its potential for severe side effects and toxicity.
Research focus
Ongoing studies are being conducted to better understand the mechanisms of action, potential therapeutic applications, and safety profile of cinobufagin.
Molecular weight
Approximately 448.51 g/mol
Appearance
A white or off-white crystalline solid
Solubility
Soluble in organic solvents such as methanol, ethanol, and acetone, but less soluble in water.
Stability
Relatively stable under normal storage conditions, but should be protected from light, heat, and moisture to maintain its potency.
Metabolism
Metabolized in the body, with some studies suggesting that it may be converted to more active metabolites.
Pharmacokinetics
The absorption, distribution, metabolism, and excretion of cinobufagin are still being researched to better understand its pharmacological properties and potential for clinical use.
Synonyms
Cinobufagin is also known as Chan Su, Chansu, and Venenum bufonum.
Regulatory status
The regulatory status of cinobufagin may vary by country, and it is important to consult local regulations and guidelines for its use in medical or research applications.
Check Digit Verification of cas no
The CAS Registry Mumber 24512-60-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,1 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24512-60:
(7*2)+(6*4)+(5*5)+(4*1)+(3*2)+(2*6)+(1*0)=85
85 % 10 = 5
So 24512-60-5 is a valid CAS Registry Number.
24512-60-5Relevant academic research and scientific papers
Cytotoxic constituents from the skin of the toad Bufo bufo gargarizans
Wu, Fu-Kai,Qiu, Ying-Kun,Zhao, Hu-Yi,Wu, Zhen,Li, Fa-Mei,Jiang, Yong-Tao,Chen, Ji-Yong
experimental part, p. 111 - 116 (2011/04/15)
To study the chemical composition of the skin of Bufo bufo gargarizans, various chromatographic methods were used in the isolation procedures and the structures of isolated compounds were determined based on NMR and MS analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-N-methylurea (1) and 19-oxocinobufotalin 3-adipoylarginine ester (2), together with 11 known compounds. Isolated bufadienolides showed significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
