24517-60-0

Upstream product

• 700-91-4 2-phenyl-1-pyrroline 
• 108-24-7 acetic anhydride 
• 16895-67-3 N-Nitroso-N-(4-phenyl-butyl)-acetamid 
• 7546-14-7 N-acetylpyridinium chloride 
• 216493-05-9 C₁₂H₁₃NO 
• 501-65-5 diphenyl acetylene 

Downstream Products

• 881040-87-5 N-[2-(5-fluoro-2-phenyl-1H-indol-3-yl)ethyl]acetamide 
• 881040-88-6 N-[2-(7-ethyl-2-phenyl-1H-indol-3-yl)ethyl]acetamide 
• 151889-03-1 2-phenylmelatonin 
• 690945-50-7 2-phenylornithine 
• 4560-07-0 N-<2-(2-phenylindol-3-yl)ethyl>acetamide 

Relevant academic research and scientific papers

Amide Oxygen-Assisted Palladium-Catalyzed Hydration of Alkynes

Herein, an amide oxygen-assisted palladium-catalyzed hydration reaction of alkynes is realized to prepare a series of o-acylacetanilide derivatives with high yield, and single regioselectivity under mild reaction conditions. This transformation is simple,

Rhodium(III)-catalyzed oxidative bicyclization of 4-arylbut-3-yn-1-amines with internal alkynes through C-H functionalization

A new Rh(III)-catalyzed oxidative bicyclization through C-H functionalization is presented. This reaction allows the selective assembly of diverse benzo[g]indoles from 4-arylbut-3-yn-1-amines and internal alkynes via a sequence of aromatic C(sp2)-H functionalization, cyclodimerization and nucleophilic cyclization.

Convenient synthesis of melatonin analogues: 2- and 3-substituted -N-acetylindolylalkylamines

A new method for the synthesis of 2- and 3-substituted indolylalkylamides, derivatives of melatonin, from arylhydrazines and amidoketones by the Fischer reaction was elaborated. The amidoketones can be easily prepared from cyclic imines by reaction with acylpyridinium chloride. This method is a one-step synchronous creation of the selected alkylamide fragment and the indole core. Variation of the arylhydrazines create the desired substituents in the carbocycle of indolylalkylamides and suitable choice of amidoketone can direct the amidoalkyl chain to the 2- or 3-position of the indole. Graphical Abstract

Elevation of HDL cholesterol by N-[4-[(aminothioxomethyl) hydrazono]-4-arylbutyl]amides

This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula wherein: R1, R2, and R3 are independently hydrogen, C1-C6 alkyl or -(CH2)0-6Ph where Ph is phenyl is optiona

A solvent effect that influences the preparative utility of N- (silylalkyl)phthalimide and N-(silylalkyl)maleimide photochemistry

The photochemistry of selected N-silylalkyl-substituted phthalimides and maleimides has been investigated with the aim of exploring the generality and preparative consequences of an intriguing solvent effect on excited-state reaction chemoselectivities and quantum efficiencies. An example of this effect is found in the photochemistry of N- [(trimethylsilyl)butyl]phthalimide 10, where irradiation in MeCN leads to production of a mixture of four products that arise by excited-state intramolecular hydrogen-atom abstraction. In contrast, the benzoindolizidine 15 is the sole product produced by a single electron transfer (SET)- desilylation pathway upon irradiation of 10 in 35% H2O-MeCN. Another example of this solvent effect is found in the photochemistry of the N-silylpropyl- maleimide 17. Irradiation in MeCN results in the production of the 2+2-dimer 19 whereas the pyrrolizidine 18 is generated exclusively by irradiation of 17 in 35% H2O-MeCN. The results of fluorescence and triplet sensitization experiments suggest that the solvent effect has multiple sources including the control of the nature, reactivity, and intrinsic lifetimes of singlet and triplet excited states of the phthalimide and maleimide systems. The exploratory studies have clearly demonstrated the generality of this solvent effect and how it can be used to enhance the preparative utility of the photochemistry of N-(silylalkyl)phthalimides and N-(silylalkyl)maleimides.