24522-49-4

Usage

Uses

Used in Organic Synthesis:
1-(4-Fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the creation of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4-Fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is used as a starting material or a building block for the development of new drugs. Its potential pharmacological properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Academic Research:
1-(4-Fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is utilized in academic research to study its chemical properties, reactivity, and potential applications. Researchers explore its behavior in different reaction conditions and its interactions with other molecules to gain insights into its use in chemical and pharmaceutical processes.
Used in Drug Discovery:
In drug discovery, 1-(4-Fluorophenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile is employed as a potential lead compound. Its unique structure and pharmacological properties make it a valuable component in the search for new therapeutic agents, particularly in the areas of cardiovascular, neurological, and other therapeutic fields.

Upstream product

• 1735-88-2 2-cyano-N-[4-(fluoro)phenyl]acetamide 
• 123-54-6 acetylacetone 

Relevant academic research and scientific papers

2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development

As part of our effort to develop new molecular targeted antitumor drug, a novel 2,7-naphthyridone-based MET kinase inhibitor, 8-((4-((2-amino-3-chloropyridin-4-yl)oxy)- 3-fluorophenyl)amino)-2-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one (13f), was identif

Discovery of 8-amino-substituted 2-phenyl-2,7-naphthyridinone derivatives as new c-Kit/VEGFR-2 kinase inhibitors

The 2,7-naphthyridone scaffold has been proposed as a novel lead structure ofMETinhibitors by our group. To broaden the application of this new scaffold, a series of 8-amino-substituted 2-phenyl-2,7-naphthyridin-1(2H)-one derivatives were designed and synthesized. Preliminary biological screening resulted in the discovery of a new lead of c-Kit and VEGFR-2 kinase inhibitors. Compound 9k exhibited excellent c-Kit inhibitory activity, with an IC50 value of 8.5 nM, i.e., it is 38.8-fold more potent than compound 3 (IC50 of 329.6 nM). Moreover, the compounds 10l and 10r exhibited good VEGFR-2 inhibitory activity, with IC50 values of 56.5 and 31.7 nM, respectively, i.e., they are 5.0-8.8-fold more potent than compound 3 (IC50 of 279.9 nM). Molecular docking experiments provided further insight into the binding interactions of the new lead compounds with c-Kit and VEGFR-2 kinase. In this study, an 8-amino-substituted 2-phenyl-2,7-naphthyridin-1(2H)-one scaffold was identified as the new lead structure of c-Kit and VEGFR-2 kinase inhibitors.

Synthesis of N-substituted 4,6-dimethyl-3-cyano-2-pyridones under microwave irradiation

N-substituted 4,6-dimethyl-3-cyano-2-pyridones have been prepared from acetylacetone, N-substituted cyanoacetamide, and pyperidine as catalyst under microwave irradiation without solvent. The rapid and simple method produced pure products in high yields. Copyright Taylor & Francis LLC.

Novel pirfenidone analogues: Synthesis of pyridin-2-ones for the treatment of pulmonary fibrosis

A new series of polysubstituted 1-aryl-2-oxo-1,2-dihydropyridine-3- carbonitriles and pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d]pyrimidine-6-carbonitriles have been synthesized and tested for their antifibrotic activity. Among the tested co