245321-50-0

Basic information

• Product Name: phosphoric acid 4-[2-(4-amino-pyrimidin-2-yl)-5-methyl-thiazol-4-yl]-phenyl ester diethyl ester
• Synonyms: phosphoric acid 4-[2-(4-amino-pyrimidin-2-yl)-5-methyl-thiazol-4-yl]-phenyl ester diethyl ester
• CAS NO: 245321-50-0
• Molecular Weight: 420.429
• Mol File: 245321-50-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phosphoric acid 4-[2-(4-amino-pyrimidin-2-yl)-5-methyl-thiazol-4-yl]-phenyl ester diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: phosphoric acid 4-[2-(4-amino-pyrimidin-2-yl)-5-methyl-thiazol-4-yl]-phenyl ester diethyl ester(245321-50-0)
• EPA Substance Registry System: phosphoric acid 4-[2-(4-amino-pyrimidin-2-yl)-5-methyl-thiazol-4-yl]-phenyl ester diethyl ester(245321-50-0)

Safety Data

• Hazardous Substances Data: 245321-50-0(Hazardous Substances Data)

Upstream product

• 70-70-2 4-hydroxypropiophenone 
• 245321-48-6 phosphoric acid diethyl ester 4-propionyl-phenyl ester 
• 245321-46-4 4-aminopyrimidine-2-carbonitrile 
• 245321-47-5 4-amino-pyrimidine-2-carbothioic acid amide 
• 245321-49-7 phosphoric acid 4-(2-bromo-propionyl)-phenyl ester diethyl ester 

Relevant articles and documents

Structure-based design of a non-peptidic antagonist of the SH2 domain of Grb2

The structure-based design and synthesis of a completely non-peptidic, micromolar antagonist of the SH2 domain of Grb2 is presented. The compound mimics the two main pharmacophores of the natural ligand, the phenylphosphate of the phosphotyrosine residue and the β-carboxamide of the X+2 asparagine, which are linked by a rigid aromatic spacer.