245359-87-9Relevant academic research and scientific papers
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3- d]thiophenes
Wrobel, Jay,Sredy, Janet,Moxham, Christopher,Dietrich, Arlene,Li, Zenan,Sawicki, Diane R.,Seestaller, Laura,Wu, Li,Katz, Alan,Sullivan, Donald,Tio, Cesario,Zhang, Zhong-Yin
, p. 3199 - 3202 (1999)
We have reported on a series of novel, potent, and selective PTPase inhibitors that function as oral antidiabetic agents. Compounds 6 and 7 are particularly notable in this regard. They were both low nanomolar inhibitors and lowered glucose in the diabeti
