24536-02-5Relevant academic research and scientific papers
On the importance of the relative stereochemistry of substituents in the formation of nine-membered lactones by ring-closing metathesis
Cusson, Jean-Philippe,Chénard, Etienne,Hanessian, Stephen
, p. 1317 - 1324 (2015)
The effects of isopropyl substituents and molar concentration of diastereomeric esters toward the formation of nine-membered unsaturated lactones, in the context of the synthesis of the intermediates of the antihypertensive drug aliskiren, have been studied
Method of inhibiting parasitic activity
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, (2008/06/13)
A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. ω (6,11 Dihydro 11 oxodibenz[b,e]oxepin 2 yl)alkanoic acids
Aultz,McFadden,Lassman
, p. 1499 - 1501 (2007/10/13)
ω-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric,-hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times m
