24536-44-5

Upstream product

• 637-81-0 ethyl-2-azidoacetate 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 103858-53-3 ethyl 6-bromo-1H-indole-2-carboxylate 
• 1024585-71-4 ethyl 1-benzyl-7-bromoisoquinoline-3-carboxylate 
• 1024585-82-7 ethyl 7-bromo-1-(2-oxo-1-p-tolylpropyl)isoquinoline-3-carboxylate 
• 1024585-80-5 ethyl 7-bromo-1-(2-oxo-1-phenylpropyl)isoquinoline-3-carboxylate 
• 1024585-72-5 ethyl 7-bromo-1-(4-methoxybenzyl)isoquinoline-3-carboxylate 
• 1024585-81-6 ethyl 7-bromo-1-(2-oxo-1-phenylbutyl)isoquinoline-3-carboxylate 
• 1007117-21-6 ethyl 4-acetyl-2-(4-bromophenyl)-5-methyl-1H-pyrrole-3-carboxylate 
• 1007117-36-3 diethyl 3-(4-bromophenyl)-5-methyl-1H-pyrrole-2,4-dicarboxylate 
• 1421933-00-7 ethyl 5-amino-2-(4-bromophenyl)-4-cyano-1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Visible-Light-Mediated Synthesis of Pyrazines from Vinyl Azides Utilizing a Photocascade Process

A convenient method for the synthesis of substituted pyrazines from vinyl azides has been developed. This method is enabled by a dual-energy and electron-transfer strategy by visible-light photocatalysis. Initially, vinyl azides are activated by a triplet sensitization process from an excited ruthenium photocatalyst in the presence of water to form dihydropyrazines, followed by a single-electron-transfer (SET) process under oxygen (air) atmosphere that leads to the tetrasubstituted pyrazines in good to excellent yields.

One-pot three-component approach to the synthesis of polyfunctional pyrazoles

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.

Synthesis of polysubstituted N-H pyrroles from vinyl azides and 1,3-dicarbonyl compounds

(Chemical Equation Presented) Two synthetic methods for tetra- and trisubstituted N-H pyrroles are presented: (i) the thermal pyrrole formation by the reaction of vinyl azides with 1,3-dicarbonyl compounds via the 1,2-addition of 1,3-dicarbonyl compounds to 2H-azirine intermediates generated in situ from vinyl azides; (ii) the Cu(II)-catalyzed synthesis of pyrroles from α-ethoxycarbonyl vinyl azides and ethyl acetoacetate through the 1,4-addition reaction of the acetoacetate to the vinyl azides. By applying these two methods, regioisomeric pyrroles can be prepared selectively starting from the same vinyl azides.

Cyclic compounds and uses thereof

Compounds of general formula (1) R1—X1—W—X2—Z1—Z2—R2 or salts thereof, exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1is an optionally substituted five- or six-membered ring group; X1is a free valency or the like; W is a divalent group represented by, e. g., general formula (2) (wherein A and B are each an optionally substituted five- to seven-membered ring; E1and E4are each optionally substituted carbon or the like; E2and E3are each oxygen or the like; and a and b are each a single bond or a double bond); X2is a divalent group constituting a straight chain moiety; Z1is a divalent cyclic group or the like; Z2is a free valency or the like; and R2is optionally substituted amino or the like.

CYCLIC COMPOUNDS AND USES THEREOF

Compounds of general formula (1) or salts thereof, exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group represented by, e. g., general formula (2) (wherein A and B are each an optionally substituted five-to seven-membered ring; E1 and E4 are each optionally substituted carbon or the like; E2 and E3 are each oxygen or the like; and a and b are each a single bond or a double bond); X2 is a divalent group constituting a straight chain moiety; Z1 is a divalent cyclic group or the like; Z2 is a free valency or the like; and R2 is optionally substituted amino or the like.