245366-57-8

Upstream product

• 296253-28-6 1-[3-O-benzyl-2,5-di-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α-L-threo-pentofuranosyl]thymine 
• 230631-18-2 1-(3-O-Benzyl-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)thymine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 296253-29-7 (1R,3R,4S,7R)-1-(hydroxymethyl)-7-benzyloxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Downstream Products

• 245366-58-9 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 284497-21-8 (1S,3R,4S,7R)-7-hydroxy-1-(hydroxymethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Convenient Syntheses of 7-Hydroxy-1-(hydroxymethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptanes: α-L-Ribo- and α-L-Xylo-Configured LNA Nucleosides

Synthesis of the diastereoisomeric LNA (locked nucleic acid) nucleosides 1-(2-O,4-C-methylene-α-L-ribofuranosyl)thymine (6) and 1-(2-O,4-C-methylene-α-L-xylofuranosyl)thymine (13) are reported via convenient reaction cascades from di-O-p-toluenesulfonyl and tri-O-methanesulfonyl nucleoside derivatives 3, 7, and 10.