24544-09-0

Upstream product

• 153625-24-2 4-amino-3,5-bis(propan-2-yl)benzonitrile 
• 140411-20-7 4-iodo-2,6-diisopropylaniline 
• 24544-04-5 2,6-diisopropylbenzenamine 

Downstream Products

• 67330-53-4 4-Methyl-2,6-diisopropyl-phenylisothiocyanat 
• 67331-16-2 1-(2,6-Diisopropyl-4-methyl-phenyl)-3-(1,2,2-trimethyl-propyl)-thiourea 
• 67331-12-8 1-(2,6-Diisopropyl-4-methyl-phenyl)-3-(1,1-dimethyl-propyl)-thiourea 
• 67331-15-1 1-(2,6-Diisopropyl-4-methyl-phenyl)-3-(1-ethyl-propyl)-thiourea 
• 67331-11-7 1-tert-Butyl-3-(2,6-diisopropyl-4-methyl-phenyl)-thiourea 
• 67331-14-0 1-(2,6-Diisopropyl-4-methyl-phenyl)-3-(1-methyl-butyl)-thiourea 
• 68065-48-5 N-(4-Methyl-2,6-diisopropylphenyl)-N'-isobutylthioharnstoff 
• 68065-49-6 N-(4-Methyl-2,6-diisopropylphenyl)-N'-butylthioharnstoff 
• 67331-13-9 1-sec-Butyl-3-(2,6-diisopropyl-4-methyl-phenyl)-thiourea 
• 68065-50-9 N-(4-Methyl-2,6-diisopropylphenyl)-N'-propylthioharnstoff 
• 67331-10-6 1-(2,6-Diisopropyl-4-methyl-phenyl)-3-isopropyl-thiourea 

Relevant academic research and scientific papers

The Second-Generation Click-to-Sense Probe for Intraoperative Diagnosis of Breast Cancer Tissues Based on Acrolein Targeting

Recently, we found that a bulky 2,6-diisopropylphenyl azide is more reactive than a simple phenyl azide toward acrolein. Herein, we conjugated tetramethylrhodamine (TAMRA) to the bulky phenyl azide and utilized it as a second-generation click-to-sense (CTS) probe to analyze cancer by targeting the cellular acrolein. Subsequently, we observed that this second-generation CTS probe could distinguish breast cancer tissues with higher sensitivity than the first-generation CTS probe. Moreover, adding Rh2(OAc)4 to the system promotes the formation of a metal carbenoid intermediate that accelerates the covalent attachment of the probe to an organelle in the cancer cells.