245450-04-8Relevant articles and documents
Heterocycle and imidazole compounds, pharmaceutical composition comprising heterocycle and imidazole derivatives as well as preparation method and application of heterocycle and imidazole compounds
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Paragraph 0136; 0137; 0138; 0141; 0142, (2017/07/20)
The invention relates to heterocycle and imidazole derivatives as well as a preparation method and a pharmaceutical application of heterocycle and imidazole derivatives, in particular to novel heterocycle and imidazole derivatives as shown in the general formula (I), a preparation method of the heterocycle and imidazole derivatives, pharmaceutical composition comprising the heterocycle and imidazole derivatives as well as an application of the heterocycle and imidazole derivatives as a therapeutic agent and particularly as a PARP (poly (ADP-ribose) polymerase) inhibitor.
Nitrogenous heterocyclic compounds
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, (2008/06/13)
The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): STR1wherein W represents 1,4-piperazinediyl, etc.; U represents NR 1 R 2 (wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and R 2 represents a hydrogen atom, etc. ), OR 4, or SR 5 ; V represents an oxygen atom, a sulfur atom, N--R 6, or CR 7 R 8, at least one of X, Y and Z represents a nitrogen atom, and the others are the same or different, and each represents a nitrogen atom or C--R A ; and D 1, D 2, D 3 and D 4 each independently represent C--R B, a nitrogen atom, an oxygen atom, a sulfur atom, etc., optional adjoining two among D 1 to D 4 are combined to represent a nitrogen atom, N--R 2A, an oxygen atom, a sulfur atom, etc., or optional adjoining two selected from D 1 to D 4 represent C--R B"" (wherein two R B"" s are combined to represent substituted or unsubstituted alicyclic alkene, substituted or unsubstituted pyrrole, substituted or unsubstituted pyrazole, etc.; or pharmaceutically acceptable salts thereof.