245473-79-4

Upstream product

• 75-08-1 ethanethiol 
• 20187-72-8 methyl 2,3-anhydro-5-O-benzyl-α-D-ribofuranoside 
• 20535-09-5 2,3-Anhydro-5-O-benzyl-β-D-ribofuranoside de methyle 

Downstream Products

• 197246-54-1 (2R,3S,4S)-1,1-bis(ethylthio)-3-methyl-4-[(tert-butyldimethylsilyl)-oxy]-5-phenylmethoxypentane-2-ol 
• 197246-57-4 [4S,6R,11R,4'S,1R,2S,1'E]-2,2-dimethyl-11-[2,4-dimethyl-5-[(tert-butyldimethylsilyl)oxy]-1-pentenyl]-4-[1-methyl-2-[(tert-butyldimethylsilyl)oxy]-3-phenylmethoxy-propyl]-1,3,7-trioxaspiroundecan-9-one 
• 197246-56-3 (4S,6R,1'R,2'S)-2,2-dimethyl-4-[1-methyl-2-[(tert-butyldimethylsilyl)-oxy]-3-phenylmethoxy-propyl]-1,3,7-trioxa-spiroundec-10-en-9-one 
• 197246-55-2 (αS,1'R,2'S)-α-[1-methyl-2-[(tert-butyldimethylsilyl)-oxy]-3-phenylmethoxy-propyl]-5-hydroxymethyl-2-furaneethanol 
• 197246-51-8 (2R,3R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]-oxy]-5-phenylmethoxy-3-methylpentane-1,2-diol 
• 197246-53-0 (1R,1'R,2'S)-1-[1-methyl-2-[(tert-butyldimethylsilyl)-oxy]-3-phenylmethoxy-propyl]-oxirane 

Relevant academic research and scientific papers

Postulated biogenesis of WS9885B and progress toward an enantioselective synthesis

(Matrix presented) WS9885B promotes the assembly of microtubules in vitro and displays cytotoxicity as potent as paclitaxel against several cancer cell lines. In this Letter, we propose a biogenesis for this architecturally complex bacterial metabolite fr

Total synthesis of FK-506. Part 1: Construction of the C16-C34 fragment

The C23-C27 1,3-diol was constructed via either Brown's crotylation - osmylation or regio- and stereoselective opening of an 2,9-anhydro-β-ribofuranoside derived from D-xylofuranose. Lewis acid catalyzed epoxide opening with a protected lithiofurfural alc