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Usage

Uses

Used in Pharmaceutical Research:
Sulclamide is used as a research compound for studying the effects and mechanisms of indapamide, a medication used to treat high blood pressure. The study of Sulclamide helps in understanding the photolytic decomposition process and its implications on the efficacy and safety of indapamide.
Used in Antimalarial Research:
Sulclamide is also used as a compound in the study of antimalarial drugs. Its role in this context is to aid researchers in identifying and developing new antimalarial compounds that can effectively combat the disease. The use of Sulclamide in this field contributes to the ongoing efforts to find better treatments for malaria, a life-threatening disease affecting millions of people worldwide.

InChI:InChI=1/C7H7ClN2O3S/c8-5-2-1-4(7(9)11)3-6(5)14(10,12)13/h1-3H,(H2,9,11)(H2,10,12,13)

Upstream product

• 70049-77-3 3-(aminosulfonyl)-4-chlorobenzoyl chloride 
• 1205-30-7 4-chloro-3-sulphamoylbenzoic acid 

Downstream Products

• 59210-30-9 4-(4-methyl-piperazin-1-yl)-3-sulfamoyl-benzamide 
• 1939-76-0 4-chloro-3-sulfamoylbenzonitrile 
• 70049-79-5 4-chloro-3-sulfamoylphenyl-2-methyl-3-indolyl-ketonimine hydrochloride 

Relevant academic research and scientific papers

1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action

The synthesis of diversely substituted 3-alkyl/aralkyl/arylamino-1,4,2- benzodithiazine 1,1-dioxides and 3-alkylaminopyrido[4,3-e]-1,4,2-dithiazine 1,1-dioxides is described. Their biological activities on pancreatic β-cells and on smooth muscle cells were compared to those of the reference ATP-sensitive potassium channel (KATP channel) openers diazoxide and 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide. The aim was to assess the impact on biological activities of the replacement of the 1,2,4-thiadiazine ring by an isosteric 1,4,2-dithiazine ring. Most of the dithiazine analogues were found to be inactive on the pancreatic tissue, although some compounds bearing a 1-phenylethylamino side chain at the 3-position exerted a marked myorelaxant activity. Such an effect did not appear to be related to the opening of KATP channels but rather reflected a mechanism of action similar to that of calcium channel blockers. Tightly related 3-(1-phenylethyl)sulfanyl-4H-1,2,4-benzothiadiazine 1,1-dioxides were also found to exert a pronounced myorelaxant activity, resulting from both a K ATP channel activation and a calcium channel blocker mechanism. The present work highlights the critical importance of an intracyclic NH group at the 4-position, as well as an exocyclic NH group linked to the 3-position of the benzo- and pyridothiadiazine dioxides, for activity on KATP channels.

Benzene-sulphonamide derivatives and their uses

Benzene-sulphonamide derivatives complying with the general formula (I): in which the different symbols have different meanings, their optical isomers and the salts pharmacologically acceptable of these derivatives, as well as their uses for drug manufacture and as radiolabelled pharmacological tools of the thromboxan A2 receptors.