245657-01-6Relevant academic research and scientific papers
The design and synthesis of bis-[4'-azido-2,2':6',2-terpyridine platinum(II)] complexes with rigid and extended linkers for studying the topology of DNA by photoaffinity labeling
Lowe, Gordon,Droz, Anne-Sophie,Park, Jenny J.,Weaver, George W.
, p. 477 - 486 (1999)
A family of bis-[4'-Azido-2,2':6',2''-terpyridine platinum(II)] complexes with linear linkers of varying length have been synthesized. They have been designed to bis-intercalate into two DNA duplexes in close proximity, the azido groups allowing the sites of intercalation to be photoaffinity labeled. The linker to Pt(II) bonds are susceptible to cleavage by thiols and cyanide ion, which is a requirement for the intended method of analysis by 2D gel electrophoresis. (C) 1999 Academic Press.
Design of scaffold-like metal-organic coordination polymers based on dinuclear zinc(II) carboxylate complexes
Dybtsev,Sokolov,Peresypkina,Fedin
, p. 225 - 230 (2007)
Two new scaffold-like metal-organic coordination polymers, [Zn 2ndc2bpe]?DMF and [Zn2ndc 2dedpbp] ?4DMF (ndc is 2,6-naphthalenedicarboxylate, bpe is trans-bis(4-pyridyl)ethylene, and dedpbp is 4,4′-diethynyl-4″,
The Covalent and Coordination Co-Driven Assembly of Supramolecular Octahedral Cages with Controllable Degree of Distortion
Bao, Shu-Jin,Xu, Ze-Ming,Ju, Yun,Song, Ying-Lin,Wang, Heng,Niu, Zheng,Li, Xiaopeng,Braunstein, Pierre,Lang, Jian-Ping
supporting information, p. 13356 - 13361 (2020/09/03)
Discovering and constructing novel and fancy structures is the goal of many supramolecular chemists. In this work, we propose an assembly strategy based on the synergistic effect of coordination and covalent interactions to construct a set of octahedral s
The role of weak interactions in controlling the mode of interpenetration in hybrid ultramicroporous materials
Bajpai, Alankriti,Lusi, Matteo,Zaworotko, Michael J.
, p. 3978 - 3981 (2017/04/11)
The aromatic core in dipyridyl linker ligands is found to impact the mode of 2-fold interpenetration in hybrid ultramicroporous materials formed by pillared square grid networks. An analysis of the crystal structures suggests that linker conformation and weak interactions between the linkers in adjacent networks might explain this phenomenon.
Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators
Kaae, Birgitte H.,Harpsoe, Kasper,Kvist, Trine,Mathiesen, Jesper M.,Molck, Christina,Gloriam, David,Jimenez, Hermogenes N.,Uberti, Michelle A.,Nielsen, Soren M.,Nielsen, Birgitte,Braeuner-Osborne, Hans,Sauerberg, Per,Clausen, Rasmus P.,Madsen, Ulf
, p. 440 - 451 (2012/06/04)
A series of compounds based on the mGluR5-selective ligand 2-methyl-6-(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to be either structural analogues of MPEP, substituted monomers, or dimeric analogues. All compounds retained mGluR5 selectivity with only weak or no activity at other mGluRs or iGluRs. The substituted analogue, 1,3-bis(pyridin-2-ylethynyl)benzene (19), is a potent negative modulator at mGluR5, whereas all other compounds lost potency relative to MPEP and showed that activity is highly dependent on the position of the nitrogen atom in the pyridine moieties. A homology modeling and ligand docking study was used to understand the binding mode and the observed selectivity of compound 19.
Synthetic nanopores for DNA sequencing
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Page/Page column 6, (2008/06/13)
A compound and methods of making thereof having the structure shown below is disclosed. Each Ar is an aromatic group. Each M is palladium, platinum, or rhenium. At least one X in the compound has an aliphatic having at least 1 carbon atom. Each x, each y,
Cytotoxicity of 2,2':6',2-terpyridineplatinum(II) complexes against human ovarian carcinoma
Lowe, Gordon,Droz, Anne Sophie,Vilaivan, Tirayut,Weaver, George W.,Park, Jenny J.,Pratt, Jonathan M.,Tweedale, Lindsay,Kelland, Lloyd R.
, p. 3167 - 3174 (2007/10/03)
2,2':6',2''-Terpyridineplatinum(II) complexes are shown to possess cytotoxicity against a number of human ovarian tumor cell lines. Many of the complexes show similar activity against cisplatin- and doxorubicin-resistant cell lines as the parental cells suggesting that there is little or no cross- resistance with cisplatin or doxorubicin. The cytotoxicity of bis[2,2':6',2''-terpyridineplatinum(II)] complexes is strongly dependent on the nature of the linker. Bis[2,2': 6',2-terpyridineplatinum(II)] complexes with a flexible linker at the 4'-position show poor cytotoxicity; by contrast bis[2,2':6',2-terpyridineplatinum(II)] complexes with rigid and short linkers at platinum(II) are strikingly effective. Several of the compounds show greater cytotoxicity against human ovarian cell lines than carboplatin, the therapeutic agent currently advocated for the treatment of human ovarian cancers.
