245657-86-7Relevant academic research and scientific papers
Syntheses and structure-activity relationships of novel 3′-difluoromethyl and 3′-trifluoromethyl-taxoids
Kuznetsova, Larissa V.,Pepe, Antonella,Ungureanu, Ioana M.,Pera, Paula,Bernacki, Ralph J.,Ojima, Iwao
scheme or table, p. 817 - 828 (2009/04/06)
A series of novel 3′-difluoromethyl-taxoids and 3′-trifluoromethyl-taxoids with modifications at the C2 and C10 positions were synthesized and evaluated for their in vitro cytotoxicities against human breast carcinoma (MCF7-S, MCF7-R, LCC6-WT, LCC6-MDR),
Trifluoromethyl- and difluoromethyl-β-lactams as useful building blocks for the synthesis of fluorinated amino acids, dipeptides, and fluoro-taxoids
Kuznetsova, Larisa,Ungureanu, Ioana Maria,Pepe, Antonella,Zanardi, Ilaria,Wu, Xinyuan,Ojima, Iwao
, p. 487 - 500 (2007/10/03)
Enantiopure 1-acyl-3-hydroxyl-4-CF2H-azetidin-2-ones and 1-acyl-3-hydroxy-4-CF3-azetidin-2-ones serve as versatile intermediates for the syntheses of CF2- and CF3-containing α-hydroxy-β-amino acids, dipeptides,
Syntheses and biological activity of C-3'-difluoromethyl-taxoids
Ojima, Iwao,Lin, Songnian,Slater, John C.,Wang, Tao,Pera, Paula,Bernacki, Ralph J.,Ferlini, Cristiano,Scambia, Giovanni
, p. 1619 - 1628 (2007/10/03)
A series of new taxoids bearing difluoromethyl group at the C-3' position and modifications at the C-10 and C-14 positions has been synthesized and their biological activities studied. The in vitro cytotoxicity assay results indicate that these newly deve
