245657-91-4Relevant academic research and scientific papers
Rotational-echo double-resonance NMR distance measurements for the tubulin-bound paclitaxel conformation
Paik, Younkee,Yang, Chao,Metaferia, Belhu,Tang, Shoubin,Bane, Susan,Ravindra, Rudravajhala,Shanker, Natasha,Alcaraz, Ana A.,Johnson, Scott A.,Schaefer, Jacob,O'Connor, Robert D.,Cegelski, Lynette,Snyder, James P.,Kingston, David G. I.
, p. 361 - 370 (2008/02/09)
The important anticancer drug Taxol (paclitaxel, PTX) owes its unique activity to its ability to bind to tubulin in a stoichiometric ratio and promote its assembly into microtubules. The conformation of the microtubule-bound drug has been the focus of num
