245662-22-0Relevant academic research and scientific papers
Impact of nature and length of linker incorporated in agonists on toll-like receptor 9-mediated immune responses
Putta, Mallikarjuna Reddy,Yu, Dong,Bhagat, Lakshmi,Wang, Daqing,Zhu, Fu-Gang,Kandimalla, Ekambar R.
experimental part, p. 3730 - 3738 (2010/08/06)
Oligodeoxynucleotides containing unmethylated CpG motifs act as ligands of Toll-like receptor 9 (TLR9). We previously reported a novel class of TLR9 agonists, referred to as immune-modulatory oligonucleotides (IMOs), in which two 11-mers of the same seque
SYNTHETIC AGONISTS OF TLR9
-
Page/Page column 42-43, (2008/12/06)
The invention provides novel oligonucleotide-based compounds that individually provide distinct immune response profiles through their interactions as agonists with TLR9. The TLR9 agonists according to the invention are characterized by specific and unique chemical modifications, which provide their distinctive immune response activation profiles.
