245676-20-4Relevant academic research and scientific papers
Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling
Sabb, Annmarie L.,Morris Husbands,Tokolics, Joseph,Stein, Reinhardt P.,Tasse, Rene P.,Boast, Carl A.,Moyer, John A.,Abou-Gharbia, Magid
, p. 1895 - 1900 (2007/10/03)
Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (K(i) = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY- 132983.
